Results 191 to 200 of about 2,066,914 (266)

Did Stora Karlsö wolves reach the island naturally or by boat? [PDF]

Proc Natl Acad Sci U S A
Janssens LA, Mech LD.
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Association of Osteosarcopenia with Functional Outcomes in Older Adult Patients Undergoing Rehabilitation. [PDF]

J Frailty Sarcopenia Falls
Mannen R, Maeda K, Inoue T, Shimizu A.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

UK dementia prevention policies and initiatives across the life-course: a scoping review (2009-2024). [PDF]

BMC Public Health
Luthra N, Islam AS.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Cascade Dams and Seasonality Jointly Structure Gut Microbiome Biogeography in <i>Saurogobio punctatus</i>. [PDF]

Microorganisms
He R, Zhou K, Ni J, Chen Z, Yao C, Fu M, Lü H, Yao W.   +7 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Intentional Intimal Tracking Via a 6-F Guiding Catheter Using a Novel Puncture Wire: The Solo Technique. [PDF]

JACC Case Rep
Liu H, Ma D, Huang Z, Han F, Chen Z, Sun X, Yang J, Xiong C, Jian L, Zhang B.   +9 more
europepmc   +1 more source