Results 161 to 170 of about 4,907,693 (364)
Play therapy - reaching the child with autism [PDF]
, 2011 This paper proposes that play therapy can be an appropriate intervention in working with children with autism in schools especially when working with children who have little in the way of social skills and poor communication.
O'Brien, Patrick, Parker, Natasha
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Frontiers in Human NeuroscienceIntroductionComplex regional pain syndrome (CRPS) is often associated with pain-related fear of movement, and virtual reality has been proposed as a potential rehabilitation intervention to overcome this issue. Therefore, this cross-sectional study aimed
Marion Dagenais +12 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The project Reaching Smallholder Women with Information Services and Resilience Strategies to Respond to Climate Change aimed to increase the climate resilience of poor women and men farmers in Africa south of the Sahara and South Asia — especially those
http://orcid.org/0000-0002-8266-0488 Ringler, Claudia; https://orcid.org/0000-0003-2829-2327 Alvi, Muzna; http://orcid.org/0000-0002-0906-222X Bryan, Elizabeth; http://orcid.org/0000-0003-4782-3074 Meinzen-Dick, Ruth +1 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Arm and Hand Movement: Current Knowledge and Future Perspective
Frontiers in Neurology, 2015 Renée eMorris, Ian Q Whishaw
doaj +1 more source
Reaching Out - Engagement through Events and Festivals - the Cathedrals of England [PDF]
, 2018 All religions are characterised by a focus around a calendar of events yet the degree to which religion permeates the event and festival sector is much overlooked and frequently misunderstood.
Curtis, S.
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source