Results 141 to 150 of about 4,907,693 (364)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Optimal control of reaching is disturbed in complex regional pain syndrome: a single-case study
, 2017 Michihiro Osumi,1 Masahiko Sumitani,2 Shin-ichiro Kumagaya,3 Shu Morioka1 1Neurorehabilitation Research Center, Kio University, Nara, 2Department of Pain and Palliative Medicine, The University of Tokyo Hospital, 3Research Center for Advanced Science and
Sumitani M +3 more
core
, 2015 All plots show the reaching trajectories across all 8 trials with each point representing the hand position at a timestep in 2-D Euclidian space mapped in degrees of visual angle. The circles are centered on the target locations for the 8 trials.
Jeffrey L. Krichmar (781258) +2 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Impairments of social interaction in a valproic acid model in mice
Frontiers in Behavioral NeuroscienceBackgroundA rodent autism spectrum disorder (ASD) model based on prenatal exposure to valproic acid (VPA) is widely recognized as a prominent model. Social behavior in rodent ASD models has primarily been evaluated through a three-chamber approach test ...
Masatoshi Ukezono +5 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
, 1998 A reaching test for quantifying hand preference (QHP task) was given to 7- to 11-year-old children with specific language impairment (SLI) or developmental coordination disorder (DCD).
Bishop, Dorothy V., Hill, Elisabeth L.
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source