Results 141 to 150 of about 4,532,035 (362)

Future movement plans interact in sequential arm movements

open access: yeseLife
Real-world actions often comprise a series of movements that cannot be entirely planned before initiation. When these actions are executed rapidly, the planning of multiple future movements needs to occur simultaneously with the ongoing action.
Mehrdad Kashefi   +6 more
doaj   +1 more source

A Neural Circuit Model for Prospective Control of Interceptive Reaching [PDF]

open access: yes, 2001
Two prospective controllers of hand movements in catching -- both based on required velocity control -- were simulated. Under certain conditions, this required velocity controlled to overshoots of the future interception point.
Beck, Peter   +3 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Reconfigurations of cortical manifold structure during reward-based motor learning

open access: yeseLife
Adaptive motor behavior depends on the coordinated activity of multiple neural systems distributed across the brain. While the role of sensorimotor cortex in motor learning has been well established, how higher-order brain systems interact with ...
Qasem Nick   +9 more
doaj   +1 more source

A Neural Circuit for Coordinating Reaching with Grasping: Autocompensating Variable Initial Apertures, Perturbations to Target Size, and Perturbations to Target Orientation [PDF]

open access: yes, 2001
A neural network model is presented, that extends principles of the VITE (vector integration to end-point) model [1, 2, 3, 4] of primate reaching to the more complex case of reach-grasp coordination.
Bullock, Daniel, Ulloa, Antonio
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Developmental Trends in Postural Adjustments During Reaching in Early Childhood

open access: yesSensors
Reaching is a fundamental motor skill essential for daily living, with over 50% of daily activities involving reaching movements. Understanding the development of postural adjustments made during reaching in early childhood is crucial for motor ...
Panchao Zhao   +3 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Barriers and Facilitators in Reaching and Supporting Parents with Intellectual Disabilities

open access: yesDisabilities
Support of parents with intellectual disabilities should be long-term and start as early as possible. They, however, often come only into view late. The aim of the present study was to examine the barriers and facilitators in reaching and supporting ...
Maroesjka Van Nieuwenhuijzen   +2 more
doaj   +1 more source

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