Results 121 to 130 of about 4,532,035 (362)
Reaching large lengths and long times in polymer dynamics simulations
, 2003 A lattice model is presented for the simulation of dynamics in polymeric systems. Each polymer is represented as a chain of monomers, residing on a sequence of nearest-neighbor sites of a face-centered-cubic lattice.
Barkema, G. T., van Heukelum, Alexander
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Gay People Are Living There: Reaching Out Beyond the Cities [PDF]
, 2009 Evaluates the 2008 Out In Africa Satellite Gay and Lesbian Film Festival in Mafikeng, South Africa. Describes the challenges and impact of bringing queer films to isolated, mainly black and poor, gay and lesbian communities and strengthening local ...
Janet Shapiro, Marion Nel
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Is UK humanities research reaching the widest possible audience? [PDF]
, 2014 Report points to 'serious dangers for the international standing of UK research' in humanities and social sciences. Today marks the launch of another report on open access, a topic area that is rapidly becoming saturated.
Eve, Martin Paul
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Impairments of social interaction in a valproic acid model in mice
Frontiers in Behavioral NeuroscienceBackgroundA rodent autism spectrum disorder (ASD) model based on prenatal exposure to valproic acid (VPA) is widely recognized as a prominent model. Social behavior in rodent ASD models has primarily been evaluated through a three-chamber approach test ...
Masatoshi Ukezono +5 more
doaj +1 more source
Erratum to: Evaluation of REACH-TX: A Community-Based Approach to the REACH II Intervention [PDF]
, 2019 Jinmyoung Cho +3 more
openalex +1 more source