Results 111 to 120 of about 4,907,693 (364)
Frontiers in Integrative Neuroscience, 2012 Research conducted over the last decades has established that the medial part of posterior parietal cortex is crucial for controlling visually guided actions in human and non-human primates.
Kostas eHadjidimitrakis +3 more
doaj +1 more source
Vigor of reaching movements: reward discounts the cost of effort.
Journal of Neurophysiology, 2018 Making a movement may be thought of as an economic decision in which one spends effort to acquire reward. Time discounts reward, which predicts that the magnitude of reward should affect movement vigor: we should move faster, spending greater effort ...
Erik M. Summerside +2 more
semanticscholar +1 more source
Kinematics of Unimpaired Reach-Grasp-Release During Robotic Assisted Reaching
, 2011 Kinematics of normal reach-to-grasp function has been investigated, described and debated. Robotic devices are increasingly being used to promote upper limb rehabilitation following neurological disease or injury such as stroke but the kinematics of ...
Hill, Kevin +3 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Relating and communicating with empathy: Reaching out by reaching in
, 2017 Empathy is a personal trait which is viewed as an essential component of patient-centred care across the health professions. The patient is a person with needs and wants and emotions. They wish to be treated with respect and understanding, and have clear
Starkey, Deborah, Rowntree, Pamela
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Neuron, 2002 The exact function of motor cortex continues to be an enigma. In this issue of Neuron, present provocative data showing that microstimulation of the precentral cortex evokes complex movements, and conclude that the motor and premotor cortex together may form a single map of complex postures.
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Quantifying effects of stochasticity in reference frame transformations on posterior distributions
Frontiers in Computational Neuroscience, 2015 Reference frame transformations are usually considered to be deterministic. However, translations, scaling or rotation angles could be stochastic. Indeed, variability of these entities often originates from noisy estimation processes.
Hooman eAlikhanian +2 more
doaj +1 more source
Reaching a genetic and molecular understanding of skeletal development.
Developmental Cell, 2002 In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors
G. Karsenty, E. Wagner
semanticscholar +1 more source