Results 91 to 100 of about 435,439 (266)
Jurnal LebesgueMathematical literacy is a very important ability that students must have because mathematical literacy supports students' mathematical abilities in many contexts that will be used in everyday life.
Mukhamad Riziq Maulana +2 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
REACT Stratejisine Yönelik Yapılmış Lisansüstü Tezlerin İncelenmesi
Sakarya Üniversitesi Eğitim Fakültesi DergisiBu çalışmanın amacı Türkiye’de REACT stratejisine yönelik olarak gerçekleştirilen tezlerin betimsel olarak analiz edilmesidir. Bu çerçevede Türkiye’de REACT stratejisine yönelik olarak yapılan lisansüstü tezlerin türlerine, hazırlandıkları üniversitelere,
Mustafa Yılmazlar, Latif Güneş
doaj +1 more source
Focused ReAct: Improving ReAct through Reiterate and Early Stop
CoRRLarge language models (LLMs) have significantly improved their reasoning and decision-making capabilities, as seen in methods like ReAct. However, despite its effectiveness in tackling complex tasks, ReAct faces two main challenges: losing focus on the original question and becoming stuck in action loops.
Shuoqiu Li +2 more
openaire +2 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Frontiers in Public HealthAntimicrobial resistance (AMR) is an escalating global threat, posing a serious challenge to public health and medical and social advancements. Top-down research methods and policy implementation approaches have fallen short in capturing the complexities
Kartik Mihir Mishra +9 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source