Results 41 to 50 of about 105,458 (263)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Solving the Caputo Fractional Reaction-Diffusion Equation on GPU

Discrete Dynamics in Nature and Society, 2014
We present a parallel GPU solution of the Caputo fractional reaction-diffusion equation in one spatial dimension with explicit finite difference approximation.
Jie Liu, Chunye Gong, Weimin Bao, Guojian Tang, Yuewen Jiang   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Maximum Principles for Discrete and Semidiscrete Reaction-Diffusion Equation

Discrete Dynamics in Nature and Society, 2015
We study reaction-diffusion equations with a general reaction function f on one-dimensional lattices with continuous or discrete time ux′  (or  Δtux)=k(ux-1-2ux+ux+1)+f(ux), x∈Z.
Petr Stehlík, Jonáš Volek
doaj   +1 more source

Convolution Representation of Traveling Pulses in Reaction-Diffusion Systems

Advances in Mathematical Physics, 2023
Convolution representation manifests itself as an important tool in the reduction of partial differential equations. In this study, we consider the convolution representation of traveling pulses in reaction-diffusion systems.
Satoshi Kawaguchi
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effect of stress-dependent activation enthalpy on electrochemical reaction and diffusion-reaction-induced stress in spherical electrodes

Results in Physics, 2019
Effect of chemical reaction on Li-ions diffusion and diffusion-reaction-induced stresses in a spherical electrode is studied, considering the reaction rate determined by the relation between hydrostatic stress and activation enthalpy, to derive new ...
Liangxinbu Lyu, Bailin Zheng, Kai Zhang, Feng Wang, Siyuan Zhan   +4 more
doaj   +1 more source

Hyers-Ulam stability of a nonautonomous semilinear equation with fractional diffusion

Demonstratio Mathematica, 2020
In this paper, we study the Hyers-Ulam stability of a nonautonomous semilinear reaction-diffusion equation. More precisely, we consider a nonautonomous parabolic equation with a diffusion given by the fractional Laplacian. We see that such a stability is
Villa-Morales José
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Spatial dynamics of a nonlocal bistable reaction diffusion equation

Electronic Journal of Differential Equations, 2020
This article concerns a nonlocal bistable reaction-diffusion equation with an integral term. By using Leray-Schauder degree theory, the shift functions and Harnack inequality, we prove the existence of a traveling wave solution connecting 0 to an ...
Bang-Sheng Han, Meng-Xue Chang, Yinghui Yang   +2 more
doaj