Results 71 to 80 of about 1,156,331 (301)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Assessment of deuteron-induced reaction mechanisms at low and medium energies

EPJ Web of Conferences, 2010
An extended analysis of the nuclear reaction mechanisms involved in the deuterons interaction with 63,65Cu is presented. First, the available elastic-scattering data analysis provided us the optical potential for reaction cross sections calculations ...
Avrigeanu V., Avrigeanu M.
doaj   +1 more source

Deformation effect on total reaction cross sections for neutron-rich Ne-isotopes

, 2011
Isotope-dependence of measured reaction cross sections in scattering of $^{28-32}$Ne isotopes from $^{12}$C target at 240 MeV/nucleon is analyzed by the double-folding model with the Melbourne $g$-matrix.
G. R. Satchler, K. Amos, Kazuyuki Ogata, Kosho Minomo, Masaaki Kimura, Masanobu Yahiro, Takenori Sumi, Yoshifumi R. Shimizu   +7 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Calculations of (n,2n) reaction cross sections for 74,76,78,80,82Se up to 20 MeV

EPJ Web of Conferences, 2016
In the present work, the excitation functions of (n,2n) reactions for five isotopes of selenium (74,76,78,80,82Se) are calculated using ALICE/ASH, EMPIRE-3.2.2, PCROSS, and TALYS 1.6 computer codes based on statistical model up to 20 MeV. The theoretical
Şahan Halide, Şahan Muhittin, Tel Eyyup   +2 more
doaj   +1 more source

Chiral dynamics in the gamma p --> pi^0 eta p and gamma p --> pi^0 K^0 Sigma^+ reactions

, 2006
Using a chiral unitary approach for meson-baryon scattering in the strangeness zero sector, where the $N^*(1535)$ resonance is dynamically generated, we study the reactions $\gamma p \to \pi^0 \eta p$ and $\gamma p \to \pi^0 K^0 \Sigma^+$ at photon ...
Doring, M., Oset, E., Strottman, D.
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Neutron-induced capture cross sections of short-lived actinides with the surrogate reaction method

EPJ Web of Conferences, 2010
Determination of neutron-capture cross sections of short-lived nuclei is opening the way to understand and clarify the properties of many nuclei of interest for nuclear structure physics, nuclear astrophysics and particularly for transmutation of ...
Gunsing F., Bauge E., Sérot O., Faul T., Pillet N., Taieb J., Gaudefroy L., Roig O., Méot V., Haas B., Dassie D., Czajkowski S., Matthieu L., Barreau G., Jurado B., Boutoux G., Aïche M.   +16 more
doaj   +1 more source