Results 151 to 160 of about 14,626,809 (402)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Graph-theoretic analysis of multistationarity using degree theory [PDF]

, 2014
Biochemical mechanisms with mass action kinetics are often modeled by systems of polynomial differential equations (DE). Determining directly if the DE system has multiple equilibria (multistationarity) is difficult for realistic systems, since they are ...
Conradi, Carsten, Mincheva, Maya
core  

Advancements in Thermo and Photothermal CO2 Hydrogenation to Light Olefins Using Fe‐Based Catalysts: Current Progress and Future Directions

Carbon Energy
The development of human industry inevitably leads to excessive carbon dioxide (CO2) emissions. It can cause critical ecological consequences, primarily global warming and ocean acidification. In this regard, close attention is paid to the carbon capture,
Timofey Karnaukhov, Blaž Likozar, Andrii Kostyniuk   +2 more
doaj   +1 more source

Methionine gamma‐lyase: The unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers [PDF]

, 2009
Dan Sato, Tomoyoshi Nozaki
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Reaction time to judge the temporal inequality of digits numbers [PDF]

, 2009
Several studies had consistently lighted mechanisms about the relation between spatial and numerical cognition; parallel to this, a separate research line begin to document similar relationships for the representation of time and quantity as well ...
Carmelo M. Vicario
core   +1 more source

reaction mechanism

, 2019
Citation: 'reaction mechanism' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.R05173 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Mechanism of the microtubule GTPase reaction

, 2021
Michael Caplow, John Shanks
openalex   +1 more source

Review of: "Severe Cutaneous Adverse Drugs Reactions: From Causes To Mechanisms" [PDF]

, 2022
Purnima Paliwal
openalex   +1 more source