Results 171 to 180 of about 14,626,809 (402)

Degradation of the Antibiotic Sulfamethoxazole by Ozonation: A Comprehensive Review

CleanMat
Sulfamethoxazole (SMX) is an antibiotic widely used for the treatment of several diseases, especially respiratory and urinary. Due to its widespread use, its presence in the environment has been on the rise.
Jéssica Martini, Joshua O. Ighalo, Ebuka Chizitere Emenike, Jordana Georgin, Elvis Carissimi   +4 more
doaj   +1 more source

Evidence for a Chelate-Induced Changeover in the Substitution Mechanism of Aquated Copper(II). Volume Profile Analyses of Water Exchange and Complex-Formation Reactions

, 1994
D. Hugh Powell, André E. Merbach, István Fábián, Siegfried Schindler, Rudi van Eldik   +4 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Challenges in Mechanistic Investigation of a Flexible Aminocatalyst as Demonstrated through Enamine Formation

ChemistryOpen
Asymmetric catalysis has become a prominent topic in synthesis over recent decades. Conformational changes in the catalyst core play a significant role in the reaction, determining both its rate and selectivity.
Irina Osadchuk, Tõnis Kanger
doaj   +1 more source

Copper(i) activation of C–X bonds: bimolecularvs.unimolecular reaction mechanism

, 2022
Guillermo Marcos-Ayuso, Agustı́ Lledós, Juan Á. Casares   +2 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Recent Advances In Low‐ and Nonnoble Metal Catalysts for Acidic Oxygen Evolution Reaction

ChemElectroChem
Water electrolysis technology is a core pathway for green hydrogen production and plays a crucial role in enabling efficient storage and conversion of clean energy.
Xinye Zhang, Mengtian Huo, Zihao Xing, Siyuan Zhu, Jinfa Chang   +4 more
doaj   +1 more source

Investigation of the reaction mechanism of [4 + 2] cyclization of 2,3 dimethylbuta-1,3-diene to methylacrylate using the Michaelis-Menten equation

, 2018
Irina Kostiv
openalex   +2 more sources

Succinylated isoniazid potential prodrug: Design of Experiments (DoE) for synthesis optimization and computational study of the reaction mechanism by DFT calculations

, 2021
Diego Campos Prieto, Renan Vinícius de Araújo, Sara de Souza Lima, Felipe Zauith Assad, Scott M. Grayson, Ataualpa Albert Carmo Braga, Felipe Rebello Lourenço, Jeanine Giarolla   +7 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source