Results 71 to 80 of about 14,001,607 (382)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Ab-Initio Molecular Dynamics Simulation of the Electrolysis of Nucleobases

Energies, 2021
Electrolysis is potentially a valuable tool for cleansing waste water. One might even hope that it is possible to synthesize valuable products in this way. The question is how the reaction conditions can be chosen to obtain desired compounds.
Irmgard Frank, Ebrahim Nadimi
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Characterization of Turing diffusion-driven instability on evolving domains [PDF]

, 2012
In this paper we establish a general theoretical framework for Turing diffusion-driven instability for reaction-diffusion systems on time-dependent evolving domains.
A. Gierer, A. M. Oster, A. Madzvamuse, A. Madzvamuse, A. Madzvamuse, A. Madzvamuse, A. Madzvamuse, A. Madzvamuse, A. Madzvamuse, A. Turing, Anotida Madzvamuse, C. Chicone, C. Varea, C. Venkataraman, D. Daners, E. J. Crampin, E. J. Crampin, G. H. Golub, Georg Hetzer, H. Amann, I. Prigogine, J. D. Murray, J. Mierczynksi, J. Mierczynski, J. Mierczynski, J. Schnakenberg, K. J. Painter, L. Edelstein-Keshet, L. Solnica-Krezel, M. Chaplain, P. K. Maini, P. Weidemaier, Q. Ouyang, R. Denk, R. Denk, R. G. Plaza, R. Schnaubelt, S. Kondo, S. S. Liaw, S. Sick, V. Castets, Wenxian Shen, Y. Latushkin, Y. Shiferaw   +43 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The Fascinating Chemistry of α‐Haloamides

ChemistryOpen, 2020
The aim of this review is to highlight the rich chemistry of α‐haloamides originally mainly used to discover new C−N, C−O and C−S bond forming reactions, and later widely employed in C−C cross‐coupling reactions with C(sp3), C(sp2) and C(sp) coupling ...
Dr. Anna Fantinati, Prof. Vinicio Zanirato, Dr. Paolo Marchetti, Prof. Claudio Trapella   +3 more
doaj   +1 more source

Reaction mechanisms involved in the production of neutron-rich isotopes

, 2003
The reaction mechanisms best suited for the production of neutron-rich nuclei, fragmentation and fission, are discussed. Measurements of the production cross sections of reaction residues together with model calculations allow to conclude about the ...
Benlliure, J., Helariutta, K., Ricciardi, M. V., Schmidt, K. -H.   +3 more
core   +1 more source

PyFrag 2019—Automating the exploration and analysis of reaction mechanisms

Journal of Computational Chemistry, 2019
We present a substantial update to the PyFrag 2008 program, which was originally designed to perform a fragment‐based activation strain analysis along a provided potential energy surface. The original PyFrag 2008 workflow facilitated the characterization
Xiaobo Sun, T. Soini, Jordi Poater, Trevor A. Hamlin, F. Bickelhaupt   +4 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source