Results 121 to 130 of about 2,953,194 (309)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

AUDIO- VISUAL REACTION TIME IN INDIAN CLASSICAL SINGERS

open access: yesNational Journal of Medical Research, 2017
Introduction: Audiovisual Reaction Time involves the time period taken for the response to auditory or visual stimuli which depends on the intactness of the sensory and the motor system.
Yuvraj Gharu, Luxmi Gharu
doaj  

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

A Theory of Reaction Time Distributions [PDF]

open access: yes, 2008
We develop a general theory of reaction time ({RT}) distributions in psychological experiments, deriving from the distribution of the quotient of two normal random variables, that of the task difficulty (top-down information), and that of the external ...
Moscoso del Prado Martin, Dr Fermin
core  

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

The nature and significance of the response latency associated with the amendment of movements of varying complexity [PDF]

open access: yes, 1975
This investigation examined variation in the reaction time (RT2) to the second of two closely paired stimuli when responses were ordered according to relative degree of movement complexity.
Siegel, Donald Steven   +1 more
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of a reaction-diffusion system of ƛ -w type [PDF]

open access: yes, 2003
The author studies two coupled reaction-diffusion equations of 'ƛ - w' type, on an open, bounded, convex domain Ω C R(^d) (d ≤ 3), with a boundary of class C(^2), and homogeneous Neumann boundary conditions.
Garvie, Marcus Roland
core  

Decision-Making Time Analysis for Assessing Processing Speed in Athletes during Motor Reaction Tasks

open access: yesSports
Reaction time (RT) is a widely used measure for testing physical performance in motor tasks. This study focused on assessing the processing speed in athletes. Twenty-five healthy volunteers were assigned to the control (n = 16) or athletes groups (n = 9).
Leonardo Ariel Cano   +5 more
doaj   +1 more source

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