Results 101 to 110 of about 5,934,007 (291)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Comparison of mental performance and sleepiness between 8 and 12 hrs shift works in an oil refinery plant in Iran [PDF]

طب کار, 2015
Background: There are different types of shift work programs, each of them has its pros and cons. The purpose of this study was to compare sleep and mental performance in 12-hour and 8-hour shift works.
M Maghsoodipour, L Khoda Bandeh Lou, L Piri   +2 more
doaj  

TÜRKİYE’DEKİ MİNİK FUTBOLCULARDA REAKSİYON ZAMANI, VİTAL KAPASİTE DEĞERLERİ VE LATERİZASYON DAĞILIMINDA SOLAKLIK SORUNU

Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi, 2007
Bu çalışmada amaç, Türkiye’deki minik futbolcularda reaksiyon zamanı ve vital kapasite değerlerinin belirlenmesi ve Türkiye’de sol kulvarda oynayabilecek futbolculardaki yetersizlik sorununun kaynağını tespit etmektir.
Osman İmamoğlu, Ertan Kılcıgil
doaj   +1 more source

Localization-delocalization transition of a reaction-diffusion front near a semipermeable wall

, 1997
The A+B --> C reaction-diffusion process is studied in a system where the reagents are separated by a semipermeable wall. We use reaction-diffusion equations to describe the process and to derive a scaling description for the long-time behavior of the ...
A. Büki, B. Chopard, B. Chopard, B. Chopard, Bastien Chopard, D. W. Fawcett, E. Ben-Naim, E. L. Cabarcos, F. Leyvraz, G. T. Barkema, G. T. Dee, H. Larralde, H. Taitelbaum, H. Taitelbaum, J. S. Langer, Jéro⁁me Magnin, L. Gálfi, M. Araujo, M. C. Cross, M. Howard, M. J. E. Richardson, Michel Droz, O. R. Anderson, S. Cornell, S. Cornell, S. Cornell, Y. E. Lee Koo, Y. E. Lee Koo, Z. Jiang, Z. Koza, Z. Koza, Zoltán Rácz   +31 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The effect of juggling on the proprioceptive and attentional abilities among older women

Frontiers in Public Health
BackgroundAge-related changes in attentional abilities can lead to a decline in body segment awareness in space. However, studies have reported that physical activity can improve proprioception among older adults, although proven activities with this ...
Jakub Malik, Natalia Główka, Wojciech Jelonek, Janusz Maciaszek   +3 more
doaj   +1 more source

Neural network approach to time-dependent dividing surfaces in classical reaction dynamics

, 2018
In a dynamical system, the transition between reactants and products is typically mediated by an energy barrier whose properties determine the corresponding pathways and rates.
Bardakcioglu, Robin Hobil, Feldmaier, Matthias, Hernandez, Rigoberto, Junginger, Andrej, Main, Joerg, Schraft, Philippe, Wunner, Guenter   +6 more
core   +1 more source