Results 81 to 90 of about 5,934,007 (291)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Global Stability of a Premixed Reaction Zone (Time-Dependent Liñan’s Problem) [PDF]

, 1990
Global stability properties of a premixed, three-dimensional reaction zone are considered. In the nonadiabatic case (i.e., when there is a heat exchange between the reaction zone and the burned gases) there is a unique, spatially one-dimensional steady ...
Adams Robert A., Carlos Alvarez Pereira, Coddington Earl A., Eidel'man S. D., Friedman Avner, Henry Daniel, Hirsch Morris W., José M. Vega, Ladyzenskaja O. A., Protter Murray H., Williams F. A.   +10 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Persistent developmental stuttering as a cortical-subcortical dysfunction: evidence from muscle activation Gagueira persistente do desenvolvimento como disfunção córtico-subcortical: evidências pela ativação muscular

Arquivos de Neuro-Psiquiatria, 2008
BACKGROUND: One contemporary view of stuttering posits that speech disfluencies arise from anomalous speech motor control. PURPOSE: To verify the rest muscle tension and speech reaction time of fluent and stuttering adults.
Claudia Regina Furquim de Andrade, Fernanda Chiarion Sassi, Fabiola Juste, Lucia Iracema Zanotto de Mendonça   +3 more
doaj   +1 more source

Class of self-limiting growth models in the presence of nonlinear diffusion [PDF]

, 2002
The source term in a reaction-diffusion system, in general, does not involve explicit time dependence. A class of self-limiting growth models dealing with animal and tumor growth and bacterial population in a culture, on the other hand are described by ...
A. K. Laird, C. Cattaneo, Deb Shankar Ray, G. Abramson, G. Klein, H. Malchow, J. Folkman, J. M. Sancho, K. K. Manne, M. Mimura, M. R. Roussel, N. Shigesada, S. Fedotov, Sandip Kar, Suman Kumar Banik, T. Hillen, V. Méndez, W. Horsthemke   +17 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Weak-strong uniqueness of solutions to entropy-dissipating reaction-diffusion equations

, 2017
We establish a weak-strong uniqueness principle for solutions to entropy-dissipating reaction-diffusion equations: As long as a strong solution to the reaction-diffusion equation exists, any weak solution and even any renormalized solution must coincide ...
Alexandre, Alexandre, Bothe, Canizo, Caputo, Dal Maso, Desvillettes, Desvillettes, Desvillettes, Desvillettes, Desvillettes, DiPerna, DiPerna, DiPerna, Feinberg, Feireisl, Feireisl, Fiebach, Fischer, Gajewski, Gajewski, Glitzky, Goudon, Julian Fischer, Kräutle, Laamri, Liero, Liero, Mielke, Mielke, Mincheva, Murat, Pierre, Pierre, Pierre, Pierre, Schuster, Villani   +37 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

An In-depth Analysis of Multisensory Reaction Time Disparities between Yogic and Non-Yogic Practitioners

Physical Education Theory and Methodology
Background. Auditory and visual reaction time refers to the duration between the introduction of a sound or light and the onset of a response. It is an important aspect of human behaviour, influencing performance in various activities ranging from daily ...
Tarak Nath Pramanik, Aminur Rahaman, Subrata Pramanick, Prasoon Chowdhuri, Rajib Dutta   +4 more
doaj   +1 more source