Results 71 to 80 of about 2,628,125 (259)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Effects of HRV biofeedback training on recovery, stress management, reaction time and concentration in competitive rowing – preliminary study [PDF]

European Journal of Translational and Clinical Medicine
Background: Our aim was to determine the effect of HRV biofeedback (HRVB) training on psychophysiological factors, e.g. reaction time, stress management and concentration during the starting period in competitive rowing.
Zuzanna Myszka, Maria Wolff, Piotr Basta, Dariusz Kozłowski   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparison of mental performance and sleepiness between 8 and 12 hrs shift works in an oil refinery plant in Iran [PDF]

طب کار, 2015
Background: There are different types of shift work programs, each of them has its pros and cons. The purpose of this study was to compare sleep and mental performance in 12-hour and 8-hour shift works.
M Maghsoodipour, L Khoda Bandeh Lou, L Piri   +2 more
doaj  

TÜRKİYE’DEKİ MİNİK FUTBOLCULARDA REAKSİYON ZAMANI, VİTAL KAPASİTE DEĞERLERİ VE LATERİZASYON DAĞILIMINDA SOLAKLIK SORUNU

Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi, 2007
Bu çalışmada amaç, Türkiye’deki minik futbolcularda reaksiyon zamanı ve vital kapasite değerlerinin belirlenmesi ve Türkiye’de sol kulvarda oynayabilecek futbolculardaki yetersizlik sorununun kaynağını tespit etmektir.
Osman İmamoğlu, Ertan Kılcıgil
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The effect of juggling on the proprioceptive and attentional abilities among older women

Frontiers in Public Health
BackgroundAge-related changes in attentional abilities can lead to a decline in body segment awareness in space. However, studies have reported that physical activity can improve proprioception among older adults, although proven activities with this ...
Jakub Malik, Natalia Główka, Wojciech Jelonek, Janusz Maciaszek   +3 more
doaj   +1 more source