Results 161 to 170 of about 5,950,394 (339)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Visual field-based reaction time as a novel indicator for early detection of mild cognitive impairment. [PDF]

Sci Rep
Tamaru Y, Inada S, Ideguchi N, Kagino S, Katsuhara Y, Higashi Y.   +5 more
europepmc   +1 more source

Real-time qPCR primers/probes and reaction conditions.

Irina Diekmann (22386241), Taniawati Supali (161356), Kerstin Fischer (131647), Elisa Iskandar (10492390), Noviani Sugianto (22097150), Yossi Destani (10492399), Rahmat Alfian (10492393), Gary J. Weil (7434074), Peter U. Fischer (7434071)   +8 more
openalex   +1 more source

Effect of Body Mass Index on Audiovisual Reaction Time in Healthy Young Males

, 2017
Brajpal Singh Tanwar, Shikha Mathur, Mamta Mamta, Aparna Garg   +3 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Enhanced Reaction Time Measurement System Based on 3D Accelerometer in Athletics. [PDF]

Sensors (Basel)
Pousibet-Garrido A, Moreno-Pérez JA, Escobedo P, Caraballo I, Gutiérrez-Manzanedo JV, González-Montesinos JL, Carvajal MA.   +6 more
europepmc   +1 more source

Front Dynamics with Time Delays in a Bistable System of the Reaction-Diffusion Type: Role of the Symmetry of the Rate Function

, 2011
R. Bakanas, Feliksas Ivanauskas, V. Jasaitis   +2 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Long-Term Health Consequences of SARS-CoV-2: Reaction Time and Brain Fog. [PDF]

Neurol Int
Lesac Brizić A, Popović B, Zavidić T, Todorović N, Petrović V, Pilipović-Broćeta N, Miljković AR, Ljubotina A, Dejhalla E.   +8 more
europepmc   +1 more source