Results 21 to 30 of about 14,718,084 (253)
L. N. Tolstoy in Lithuanian periodicals (end of 19th cent.–first decade of 20th cent.)
Literatūra (Vilnius), 1969 L. N. Tolstoy's influence upon the cultural life of Lithuania has not been properly studied though it is of great importance. In the article presented some light has been thrown upon the dissemination of L. N.
Birutė Masionienė
doaj +1 more source
Urdu Journal 200 Years : An Analysis
Journal of Mass Communication, 2019 Urdu Journalism in sub-continent shall turn 200 years old after few years. It has transformed tremendously in terms of news writing, vocabulary, lay-out, make-up and visual appeal.
Muhammad Irfan, Touseef Ahmed Khan
doaj +1 more source
‘Representing Ireland in the Periodical Press During 1848
ABEI Journal, 2009 The year of revolutions, 1848, stimulated a passionate discussion of Irish politics in the British and Irish periodical press. This article considers the range and nature of that debate.
Malcolm Ballin
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Reactionary Nationalism and Fascism: The German Case
, 2019 This article focuses on the complex relationship between National Socialists and reactionary nationalists, including members and supporters of the conservative German National People’s Party and the conservative bourgeoisie between 1929 and the onset of ...
Hermann Beck, Beck, Hermann
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
“Its Not Enough”—Mental Illness and U.S. Gun Policy
Voices in Bioethics, 2015 A senseless act of violence carried out in a public setting has once again profoundly disturbed the people of the United States. On October 1st, 2015, 26-year-old gunman Christopher Harper-Mercera killed nine people and wounded nine others at Umpqua ...
Andrew Hawkins
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source