Results 41 to 50 of about 14,718,084 (253)
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Journal of Global FaultlinesThis article explores the implications of Xi Jinping’s recent visit to Riyadh and China’s position in the Arab World vis-à-vis the USA. In particular, it will observe Saudi media perceptions of a rising China.
Niv Horesh
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
How do mainstream politicians and pundits contribute to the normalisation of far-right ideas, even as they claim to reject racism and populism? That’s one of many vital questions asked by Aaron Winter and Aurelien Mondon in their book, Reactionary ...
Winter, Aaron, Mondon, Aurelien
core +2 more sources
The Image of Korean Emperor Gojong in Russian Public Opinion and Historiography
Vestnik MGIMO-UniversitetaThis article reconstructs the formation and transformation of the image of Korean Emperor Gojong in Russia, from his lifetime to Soviet and post-Soviet historiography.
M. V. Medovarov
doaj +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Reflexiones sobre la controversia clericomasónica en la Restauración y Segunda República
Studia Historica: Historia Contemporánea, 2010 RESUMEN: Durante la primera fase de la Restauración alfonsina la masonería fue el arma esgrimida por el clericalismo español, internamente muy dividido y enfrentado, para atacar la política liberal así como para evitar que triunfase una transacción de ...
José- Leonardo RUIZ SÁNCHEZ
doaj