Results 41 to 50 of about 2,254 (262)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Antimodernism, Reactionary Modernism and National Socialism. Technocratic Tendencies in Germany, 1890–1945. [PDF]
, 1999 The article looks critically at attempts to explain the rise of National Socialism in Germany by trying to identify a peculiarly German tradition of antimodernism or reactionary modernism (by, among others, Jeffrey Herf).
Rohkramer, Thomas
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Democracy for Impertinent Citizens
, 2019 The article argues for the thesis that the impertinent citizen - likewise the shameless and unashamed citizen - is an ambivalent figure. Democratically, he seems to be as necessary as he is dangerous.
Früchtl, Josef
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Race, gender, and Occidentalism in global reactionary discourses
This article seeks to deepen understanding of the global politics of reactionary discursive formations, which at the current conjuncture increasingly coalesce around self-victimising articulations of racial nationalism and a rejection of social justice ...
Zhang, Chenchen
core +1 more source
Tensions of a Free Press: South Africa After Apartheid
, 2023 A vigorous debate has developed over what should be the role of journalists within the new post-apartheid political context. Questions are raised about the media and the “national interest” as well as the impact of racial patterns of ownership and ...
Jacobs, Sean
core
Journal of Global FaultlinesThis article explores the implications of Xi Jinping’s recent visit to Riyadh and China’s position in the Arab World vis-à-vis the USA. In particular, it will observe Saudi media perceptions of a rising China.
Niv Horesh
doaj +1 more source