Results 51 to 60 of about 2,254 (262)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Die Schattenseiten des amerikanischen Konservatismus: Corey Robin und George Hawley fragen nach dem radikalen Potenzial einer ehrwürdigen politischen Tradition [PDF]
, 2018 George Hawley: Making Sense of the Alt-Right. New York: Columbia University Press 2017. 9780231546003 +++ Corey Robin: The Reactionary Mind: Conservatism from Edmund Burke to Donald Trump. New York: Oxford University Press 2018.
Adler-Bartels, Tobias
core
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A.W.N. Pugin's "True Principles" Gothic Furniture: Evolutionary, Revolutionary, Reactionary? [PDF]
, 2017 First paragraph: However much we may be indebted to those ancient supporters of Pointed Architecture who, faithfully adhering to its traditions at a period when the style fell into general disuse, strove earnestly, and in some instances ably, to preserve
Lindfield, Peter
core
Rationalizing Journalistic Mistakes and Failures:Digital press criticism and the defense of autonomy [PDF]
Digital press criticism means public evaluations and sentiments about the news and journalists, expressed, shared, interpreted, and distributed in digital spaces.
Cheruiyot, David; id_orcid +1 more
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
, 2017 The London Mercury attained popularity and notoriety as the leading anti-modernist voice of the early 1920s. It reached more than 10,000 circulation by presenting itself as a voice of reason in an age of critical anarchy, and its material form ...
Patrick Collier
core +1 more source
Reflexiones sobre la controversia clericomasónica en la Restauración y Segunda República
Studia Historica: Historia Contemporánea, 2010 RESUMEN: Durante la primera fase de la Restauración alfonsina la masonería fue el arma esgrimida por el clericalismo español, internamente muy dividido y enfrentado, para atacar la política liberal así como para evitar que triunfase una transacción de ...
José- Leonardo RUIZ SÁNCHEZ
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source