Results 121 to 130 of about 26,803 (327)

A Proof‐of‐Concept Assessment of a Novel Wearable Eyelid Muscle Device: A Pre‐Clinical Animal Cadaver Study for Eyelid Closure Restoration

Advanced Robotics Research, EarlyView.
This article introduces a soft wearable eyelid sling device incorporating a hydraulic soft artificial muscle (SAM) for achieving complete closure of an eyelid. The SAM is driven by a cam mechanism that provides a displacement profile closely matched with those of a healthy eyelid.
Patrick Pruscino, Phuoc Thien Phan, James Davies, Bibhu Sharma, Tianruo Guo, Chi Cong Nguyen, Nigel H. Lovell, Thanh Nho Do   +7 more
wiley   +1 more source

Pyrimidine Triones as Potential Activators of p53 Mutants

Biomolecules
p53 is a crucial tumor suppressor in vertebrates that is frequently mutated in human cancers. Most mutations are missense mutations that render p53 inactive in suppressing tumor initiation and progression.
Maryam M. Jebril Fallatah, Özlem Demir, Fiona Law, Linda Lauinger, Roberta Baronio, Linda Hall, Elodie Bournique, Ambuj Srivastava, Landon Tyler Metzen, Zane Norman, Rémi Buisson, Rommie E. Amaro, Peter Kaiser   +12 more
doaj   +1 more source

Stability of DNA Patterns and Evidence ofMycobacterium tuberculosisReactivation Occurring Decades after the Initial Infection [PDF]

, 2003
Troels Lillebæk, Asger Dirksen, Emilia Vynnycky, I. Baess, Vibeke Østergaard Thomsen, Åse Bengård Andersen   +5 more
openalex   +1 more source

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source

Neuronal Cell Model and Methods of Use Thereof [PDF]

, 2003
We previously described a novel in vitro model of a non-productive herpes simplex virus type 1 (HSV-1) infection in neurally-differentiated (ND)-PC12 cells that allows for inducible virus replication upon forskolin and heat stress (HS) treatment. In this
Danaher, Robert J., Jacob, Robert J., Miller, Craig S.   +2 more
core   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34+ Cells [PDF]

, 2018
Sebastian J. Theobald, Sahamoddin Khailaie, Michael Meyer‐Hermann, Valery Volk, Henning Olbrich, Simon Danisch, Laura Gerasch, Andreas Schneider, Christian Sinzger, Dirk Schaudien, Stefan Lienenklaus, Peggy Riese, Carlos A. Guzmán, Constança Figueiredo, Constantin von Kaisenberg, Loukia M. Spineli, Stephanie Glaesener, Almut Meyer‐Bahlburg, Arnold Ganser, Michael Schmitt, Michael Mach, Martin Messerle, Renata Stripecke   +22 more
openalex   +1 more source

Disease reactivation in a patient with secondary progressive multiple sclerosis after switching treatment from fingolimod to siponimod

, 2021
Kensuke Senzaki, Hirofumi Ochi, Masayuki Ochi, Yôko Okada, Shiroh Miura, Yasumasa Ohyagi   +5 more
openalex   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

The Mechanism by Which Oximes Reactivate Cholinesterases Inhibited by Organophosphates [PDF]

, 2013
The enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are inhibited by nerve agents such as sarin and tabun. In general, the inhibited enzymes are reactivated by bisquaternary ammonium compounds (oximes).
Bhavaraju, Manikanthan Hari Naga Venkata
core   +1 more source