Results 51 to 60 of about 911,616 (284)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The longitudinal relationship between executive dysfunction and reactive and proactive aggression in adolescents: impulsivity as a mediator and sex differences

Frontiers in Psychiatry
BackgroundAdolescent aggression poses a significant threat to mental health and social functioning. This study investigated the underlying mechanisms of reactive and proactive aggression in Chinese adolescents, focusing on the roles of executive ...
Xiaojie Su, Xiaojie Su, Wenjie Li, Changsheng Hu, Huimin Liu, Rong Lian   +5 more
doaj   +1 more source

Empathy and rejection sensitivity in relation to reactive, proactive and relational aggression in 10- to 12-year-old children. [PDF]

, 2007
The hypothesis that empathy inhibits aggression and therefore that a deficit in empathy may underlie aggressive behaviour (Feshbach, 1978) was investigated in this review.
Reilly, N.L.
core  

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

The brain and aggression: Interventions for reducing interpersonal reactive aggression

Current Opinion in Psychology
Aggression is a pernicious social problem. We present a neurocognitive model of reactive aggression and view four potential treatments through the lens of this model. These interventions include mindfulness, cognitive-behavioral therapies, omega-3s (e.g., fish oils), and selective serotonin reuptake inhibitors.
Thomas F. Denson, Robert James Blair, Lisa Wagels, Mikhail Votinov, Ute Habel   +4 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Differential Risk Profiles for Reactive and Proactive Aggression [PDF]

Social Psychology, 2017
Abstract. This two-wave longitudinal study identified configurations of social rejection, affiliation with aggressive peers, and academic failure and examined their predictivity for reactive and proactive aggression in a sample of 1,479 children and adolescents aged between 9 and 19 years.
Jung, Janis, Krahé, Barbara, Busching, Robert   +2 more
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Aggressiveness in the HEXACO personality model [PDF]

Psihologija, 2018
The a im of this research was to examine the relations between the HEXACO facets and aggressiveness components (anger, vengefulness, domination, hostility, reactive aggression, proactive aggression, and indirect aggression).
Sokolovska Valentina, Dinić Bojana M., Tomašević Aleksandar   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source