Results 61 to 70 of about 911,616 (284)

The Role of Hostile Attributions in the Associations between Child Maltreatment and Reactive and Proactive Aggression [PDF]

, 2016
This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Aggression, Maltreatment and Trauma on October 8th, 2016, available online: http://www.tandfonline.com/10.1080/10926771.2016.1231148.The present study examined the ...
Richey, Allora, Bortolato, Marco, Fite, Paula J., Brown, Shaquanna   +3 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Aggressive behavior, boredom, and protective factors among college students during closed-off management of the COVID-19 pandemic in China

Frontiers in Psychology, 2022
BackgroundChinese colleges have implemented strict closed-off management in response to the outbreak of a new variant of the new coronavirus, Omicron. But such management measures may lead to more aggressive behavior.
Yujie Li, Xiaoyi Chu
doaj   +1 more source

Gangs, displaced, and group-based aggression [PDF]

, 2010
Many urban areas experienced an alarming growth of gang activity and violence during the end of the 20th and the beginning of the 21st centuries. Gang members, motivated by various factors, commit a variety of different types of violent acts towards ...
Hennigan, Karen, Vasquez, Eduardo A., Lickel, Brian   +2 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Repeated exposure to media violence is associated with diminished response in an inhibitory frontolimbic network. [PDF]

PLoS ONE, 2007
BACKGROUND: Media depictions of violence, although often claimed to induce viewer aggression, have not been shown to affect the cortical networks that regulate behavior.
Christopher R Kelly, Jack Grinband, Joy Hirsch   +2 more
doaj   +1 more source

The stability of reactive and proactive aggression

, 2007
Background: Earlier research has shown that the stability of aggressive behavior is mainly due to genetic influences. It has been argued that aggressive behavior can be divided into reactive (impulsive, affective, ‘‘hot-blooded’’) and proactive (planned,
Raine, Adrian,, Tuvblad, Catherine,, Baker, Laura A.,   +2 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cognitive pathways to the forms and functions of aggression in adolescence: the role of early maladaptive schemas and social information processing

Frontiers in Psychology
IntroductionEarly maladaptive schemas (EMSs) have been found to associate to aggressive behavior, though the cognitive pathways underlying that association remain scarcely investigated, particularly considering the different forms and functions of ...
Paula Vagos, Paula Vagos, Matteo Angelo Fabris, Daniel Rijo   +3 more
doaj   +1 more source