Results 81 to 90 of about 860,719 (230)

Proactive and reactive sibling aggression and adolescent

, 2015
Existing research on aggression tends to narrowly focus on peers; less is known about sibling aggression, most likely due to its historical acceptance. Aggression is characterized by its forms (i.e., physical vs.
Sharp, Erin Hiley, Tucker, Corinna Jenkins, Wiesen-Martin, Desiree, Van Gundy, Karen T., Rebellon, Cesar J., Stracuzzi, Nena F.   +5 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The stability of reactive and proactive aggression

, 2007
Background: Earlier research has shown that the stability of aggressive behavior is mainly due to genetic influences. It has been argued that aggressive behavior can be divided into reactive (impulsive, affective, ‘‘hot-blooded’’) and proactive (planned,
Raine, Adrian,, Tuvblad, Catherine,, Baker, Laura A.,   +2 more
core   +1 more source

An Investigation into Theoretical State Aggression and the Difficulties Surrounding its Psychometric Quantification [PDF]

To date, the General Aggression Model has been the most extensive method of measuring aggression, with media violence being used as a strong influence on aggressive behaviour within a western society.
Colligan, Ashleigh
core   +3 more sources

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Lower levels of classroom aggression predict stronger relations between peer victimization and reactive versus proactive aggression

, 2022
We examined the concurrent relations of children\u27s reactive and proactive aggression with their experience of peer victimization. Extending previous research, we assessed these relations at both the child and classroom levels.
Hubbard, Julie A, Docimo, Marissa A, Morrow, Michael T, Swift, Lauren E, Grassetti, Stevie N, Cabanas, Katherine L, Bookhout, Megan K   +6 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Volume 1: Risk factors for aggression in childhood and adolescence. Volume 2: Selective attention to emotional facial expressions in aggressive adolescent males

, 2009
This thesis consists of two volumes. The first is a literature review exploring the development of aggression in adolescent males with a summary of research that outlines a complex multi-factor trajectory across the lifespan towards aggression in males ...
Horton, Philip
core   +1 more source