Results 81 to 90 of about 911,616 (284)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Specific cortical and subcortical alterations for reactive and proactive aggression in children and adolescents with disruptive behavior

NeuroImage: Clinical, 2020
Maladaptive aggression, as present in conduct disorder (CD) and, to a lesser extent, oppositional defiant disorder (ODD), has been associated with structural alterations in various brain regions, such as ventromedial prefrontal cortex (vmPFC), anterior ...
Jilly Naaijen, Leandra M Mulder, Shahrzad Ilbegi, Sanne de Bruijn, Renee Kleine-Deters, Andrea Dietrich, Pieter J Hoekstra, Jan-Bernard C Marsman, Pascal M Aggensteiner, Nathalie E Holz, Boris Boettinger, Sarah Baumeister, Tobias Banaschewski, Melanie C Saam, Ulrike M E Schulze, Paramala J Santosh, Ilyas Sagar-Ouriaghli, Mathilde Mastroianni, Josefina Castro Fornieles, Nuria Bargallo, Mireia Rosa, Celso Arango, Maria J Penzol, Julia E Werhahn, Susanne Walitza, Daniel Brandeis, Jeffrey C Glennon, Barbara Franke, Marcel P Zwiers, Jan K Buitelaar   +29 more
doaj   +1 more source

Peer Relations and Peer Deviance as Predictors of Reactive and Proactive Aggression among High School Girls

, 2016
This study aimed to investigate associations between reactive and proactive aggression and peer relations and peer deviance among high school girls. A total of 442 high school students participated in this study.
UZ BAŞ, ASLI, ÖZ SOYSAL, FATMA SELDA
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Factorial Analysis and Invariance Testing for Age and Gender of the Reactive-Proactive Aggression Questionnaire (RPQ)

International Journal of Psychological Research, 2020
Reactive aggression is characterized by high emotional activation, impulsivity, and hostility, while proactive aggression presents a cold, instrumental, and planned strategy.
Ronald Alberto Toro Tobar, Juan García-García, Flor Zaldívar- Basurto   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Cannabis and aggression : differentiating reactive and instrumental aggression

, 2015
My thesis explored the relation between cannabis use (CU) and two distinct subtypes of aggression. Substantial prior research has examined the association between CU and aggression; however, empirical evidence has not yet provided a clear or complete picture of this relationship.
openaire   +1 more source

Popularity Differentially Predicts Reactive and Proactive Aggression in Early Adolescence [PDF]

, 2016
Previous research has indicated that peer popularity is associated with aggressive behavior. However, it is not yet clear whether popularity is uniquely related to different functions of aggression.
Stoltz, Sabine E.M.J., Leerstoel Vollebergh, Rob Gommans, Gommans, R., Sabine Stoltz, Yvonne H.M. van den Berg, van den Berg, Yvonne, Cillessen, Antonius H. N., Cillessen, A.H.N., Berg, Y.H.M. van den, Antonius H.N. Cillessen, Stoltz, S.E.M.J., Youth in Changing Cultural Contexts   +12 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source