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Endocannabinoids and Reactive Nitrogen and Oxygen Species in Neuropathologies

Journal of Neuroimmune Pharmacology, 2006
Neuropathologies that affect our population include ischemic stroke and neurodegenerative diseases of immune origin, including multiple sclerosis. The endocannabinoid system in the brain, including agonists anandamide (arachidonyl ethanolamide) and 2-arachidonoylglycerol, and the CB1 and CB2 cannabinoid receptors, has been implicated in the ...
Allyn C, Howlett   +2 more
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The interdependence of the reactive species of oxygen, nitrogen, and carbon

Journal of Physiology and Biochemistry, 2012
This mini-review tries to summarize the main interdependences between the free radicals of oxygen, nitrogen, and carbon. Also, the main metabolic pathways for these radical species are described, as well as how these affect their interaction and functional implications.
Walther, Bild   +3 more
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Reactive oxygen and nitrogen species: Friends or foes?

Biochemistry (Moscow), 2005
Chemical and physiological functions of molecular oxygen and reactive oxygen species (ROS) and existing equilibrium between pools of pro-oxidants and anti-oxidants providing steady state ROS level vital for normal mitochondrial and cell functioning are reviewed.
D B, Zorov   +7 more
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Ras Regulation by Reactive Oxygen and Nitrogen Species

Biochemistry, 2006
Ras GTPases cycle between inactive GDP-bound and active GTP-bound states to modulate a diverse array of processes involved in cellular growth control. We have previously shown that both NO/O(2) (via nitrogen dioxide, (*)NO(2)) and superoxide radical anion (O(2)(*)(-)) promote Ras guanine nucleotide dissociation.
Jongyun, Heo, Sharon L, Campbell
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Reactive nitrogen and oxygen species in airway inflammation

European Journal of Pharmacology, 2001
The free radical nitric oxide (NO) is an important mediator of many biological processes. Interestingly, the molecule appears to be a two-edged sword. Apart from NO having a function as a paracrine messenger, NO-derived oxidants are important weapons against invading pathogens. The role of NO in the airways is similarly ambiguous. Besides the task as a
Folkerts, G.   +3 more
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Reactive Oxygen and Nitrogen Species in Alzheimers Disease

Current Alzheimer Research, 2004
Age- related neurodegenerative diseases, especially Alzheimer's disease (AD), are an important health problem globally. AD is clinically characterized by loss of memory, reasoning and speech. The frequency of the disease reaches to 20-40% in the population over the age of 85.
Mutay, Aslan, Tomris, Ozben
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Interactions between nitric oxide, oxygen, reactive oxygen species and reactive nitrogen species

Biochemical Society Transactions, 2006
ROS (reactive oxygen species) and RNS (reactive nitrogen species) are central to the innate immunity that protects us from infection, but also contribute to degenerative diseases and possibly aging. However, ROS and RNS are increasingly recognized to contribute to physiological signalling. This review briefly describes the main interactions between ROS
Brown, Guy C., Borutaitė, Vilmantė
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Detection of reactive oxygen and reactive nitrogen species in skeletal muscle

Microscopy Research and Technique, 2001
AbstractReactive oxygen species (ROS) and reactive nitrogen species (RNS) are usually identified with pathological states and mediators of cellular injury. However, over the last decade ROS and RNS have been identified in skeletal muscle under physiological conditions.
C L, Murrant, M B, Reid
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[Reactive nitrogen and oxygen species].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2010
Reactive nitrogen species (RNS) and reactive oxygen species (ROS) are mainly free radicals which including non-paired electrons. They are constantly formed as side products of biological reactions. They are also generated directly and indirectly by the cells which were exposed to environmental stress, i.e., UV radiation, ionizing radiation ...
Helena, Puzanowska-Tarasiewicz   +2 more
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Reactive Oxygen and Nitrogen Species

2004
The term “radical” is often used loosely in chemistry to refer to various groups of atoms that behave as a unit, such as the carbonate radical (CO 3 sup2- ), nitrate radical (NO 3 sup- ), and the methyl radical (CH3p-). According to this definition, Lavoisier (1789) has already indicated that the four elements: phosphorus, sulphur, carbon, and hydrogen
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