Results 201 to 210 of about 457,331 (261)

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

open access: yesAdvanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao   +19 more
wiley   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

open access: yesAdvanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie   +12 more
wiley   +1 more source

Reactive oxygen species (ROS)-mediated M1 macrophage-dependent nanomedicine remodels inflammatory microenvironment for osteoarthritis recession. [PDF]

open access: yesBioact Mater
Xue C   +12 more
europepmc   +1 more source
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Reactive oxygen species (ROS)

Journal of Materials Chemistry B, 2021
Reactive oxygen species (ROS) are generated in cellular metabolism and are essential for cellular signalling networks and physiological functions. However, the functions of ROS are 'double-edged swords' to living systems that have a fragile redox balance between ROS generation and elimination.
He, Zhonglei   +6 more
openaire   +1 more source

Reactive Oxygen Species (ROS) and Reproduction

1994
The role of reactive oxygen species (ROS) in reproduction has long been the subject of investigation. As for other systems described in this book, there is compelling evidence for the involvement of ROS in physiology and pathology of both male and female reproductive systems. In this chapter, we will first briefly summarize informations linking ROS and
E, de Lamirande, C, Gagnon
openaire   +2 more sources

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