Results 171 to 180 of about 1,362,026 (232)

Molecular similarity in chemical informatics and predictive toxicity modeling: from quantitative read-across (q-RA) to quantitative read-across structure-activity relationship (q-RASAR) with the application of machine learning. [PDF]

Crit Rev Toxicol
Banerjee A, Kar S, Roy K, Patlewicz G, Charest N, Benfenati E, Cronin MTD.   +6 more
europepmc   +1 more source

Repeat-dose toxicity prediction with Generalized Read-Across (GenRA) using targeted transcriptomic data: A proof-of-concept case study. [PDF]

Comput Toxicol, 2021
Tate T, Wambaugh J, Patlewicz G, Shah I.
europepmc   +1 more source

(Q)SARs to Predict Environmental Toxicities: Current Status and Future Needs [PDF]

The current state of the art of (Quantitative) Structure-Activity Relationships ((Q)SARs) to predict environmental toxicity is assessed along with recommendations to develop these models further.
Cronin, MTD
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Read-Across of Biotransformation Potential between Activated Sludge and the Terrestrial Environment: Toward Making It Practical and Plausible. [PDF]

Environ Sci Technol
Coll C, Screpanti C, Hafner J, Zhang K, Fenner K.   +4 more
europepmc   +1 more source

Application of grouping and read-across for the evaluation of parabens of different chain lengths with a particular focus on endocrine properties. [PDF]

Arch Toxicol, 2021
Fayyaz S, Kreiling R, Sauer UG.
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

A systematic analysis of read-across within REACH registration dossiers. [PDF]

Comput Toxicol
Patlewicz G, Karamertzanis P, Friedman KP, Sannicola M, Shah I.   +4 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Comparing the performance and coverage of selected <i>in silico</i> (liver) metabolism tools relative to reported studies in the literature to inform analogue selection in read-across: A case study. [PDF]

Comput Toxicol, 2022
Boyce M, Meyer B, Grulke C, Lizarraga L, Patlewicz G.   +4 more
europepmc   +1 more source