Results 141 to 150 of about 1,362,093 (292)
Competency-based assessment for the training of PhD students and early-career scientists. [PDF]
, 2018 The training of PhD students and early-career scientists is largely an apprenticeship in which the trainee associates with an expert to become an independent scientist.
Freedman, Victoria H. +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Kurt Semm and the fight against skepticism : endoscopic hemostasis, laparoscopic appendectomy, and Semm's impact on the "laparoscopic revolution" [PDF]
, 1998 In the 1970s, Semm developed thermocoagulation, adapted the Roeder Loop, and further invented extra- and intracoporeal endoscopic knotting to achieve endoscopic hemostasis. His numerous technical inventions, especially the electronic insufflator, allowed
Litynski, Grzegorz S.
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Quantifying Analogue Suitability for SAR-Based Read-Across Toxicological Assessment. [PDF]
Chem Res Toxicol, 2023 Lester C, Byrd E, Shobair M, Yan G.
europepmc +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Nature CommunicationsMetagenomic binning is a culture-free approach that facilitates the recovery of metagenome-assembled genomes by grouping genomic fragments. However, there remains a lack of a comprehensive benchmark to evaluate the performance of metagenomic binning ...
Haitao Han, Ziye Wang, Shanfeng Zhu
doaj +1 more source
Lagniappe: Read across the County
North Carolina LibrariesNew Hanover County Public Library (NHCPL) has developed Read across the County (RaC), a county-wide reading initiative designed to foster meaningful connections within our community. Inspired by national programs like One Book One Community, RaC aims to bring people of different backgrounds and ages together for a shared summer of reading.
Melissa Raymer +2 more
openaire +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source