Results 71 to 80 of about 1,362,093 (292)
In Silico Prediction of Organ Level Toxicity: Linking Chemistry to Adverse Effects [PDF]
, 2017 In silico methods to predict toxicity include the use of (Quantitative) Structure-Activity Relationships ((Q)SARs as well as grouping (category formation) allowing for read-across.
Cronin, M.T.D +5 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Journal of Cheminformatics, 2017 Computational prediction of the interaction between drugs and targets is a standing challenge in the field of drug discovery. A number of rather accurate predictions were reported for various binary drug–target benchmark datasets.
Tong He +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Guidance on the establishment of the residue definition for dietary risk assessment
EFSA Journal, 2016 EFSA has asked the Panel on Plant Protection Products and their Residues to prepare guidance on the establishment of the residue definition for dietary risk assessment.
EFSA Panel on Plant Protection Products and their Residues (PPR)
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Teaching Reading across the Curriculum
Theory and Practice in Language Studies, 2011 Hand-in-hand with the current renewed emphasis on students’ success and a resurgence of reading across the curriculum, teachers (instructors) in all disciplines need to refocus on reading across the curriculum to address students’ needs to achieve instructional goals, and to prepare citizens for independent learning.
Hanna Onyi Yusuf, Agnes Ovayioza Enesi
openaire +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
A Compendium of Case Studies that Helped to Shape the REACH Guidance on Chemical Categories and Read Across [PDF]
, 2007 This document pulls together the compendium of case studies that were conducted as part of the REACH project charged with developing technical guidance on the use and formation of chemical grouping approaches (chemical categories/read-across).
TIER GRACE, WORTH ANDREW
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source