Results 81 to 90 of about 1,362,093 (292)
Research to support the development of teacher training and guidance. [PDF]
, 2018 This report in conjunction with a new quality framework for delivering career guidance in schools, will be the foundation of a new web-based resource which will help teachers in schools across Europe to develop their provision in response to these issues.
Hanson, Jill, Moore, Nicki
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Business school techspectations Technology in the daily lives and educational experiences of business students [PDF]
, 2010 Business School Techspectations is the second in a series of reports based on research by the DCU Leadership, Innovation and Knowledge Research Centre (LInK) at DCU Business School.
Alexopoulos, Angelos, Lynn, Theo
core
Adverse Outcome Pathway (AOP) Informed Modeling of Aquatic Toxicology: QSARs, Read-Across, and Interspecies Verification of Modes of Action. [PDF]
Alternative approaches have been promoted to reduce the number of vertebrate and invertebrate animals required for the assessment of the potential of compounds to cause harm to the aquatic environment.
Cronin, MTD +4 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Looping, Grouping and Aligning the Vowels [PDF]
, 2005 Firstly, a reminder that an AEIOU word is one in which the 5 major vowels occur just once, in any order. The AEIOU words of current concern, however, are limited to those in which the vowels occur in alphabetical circular order or reverse alphabetical ...
Thorpe, Susan
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Bridging science and curriculum: preparing future leaders in computational toxicology
Frontiers in ToxicologyComputational toxicology plays an important role in chemical safety assessments. Computational methods are applied to early-stage screening in drug discovery, hazard identification, and regulatory safety assessment.
Frances Hall, Candice Johnson
doaj +1 more source
Generation M2: Media in the Lives of 8- to 18-Year-Olds [PDF]
, 2010 Examines trends in which media youth use, for how much time, how new media platforms have affected media consumption, what role mobile and online media play, what media environment youth live in, and how patterns vary by gender, age, and race ...
Donald F. Roberts +2 more
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source