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ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
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Towards systematic read-across using Generalised Read-Across (GenRA)
2022Presentation to OECD on April 19, 2023 (Virtual) Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=& ...
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Generalized Read-across (GenRA) – Data driven systematic read-across approaches
2020Hands-on Training: Practical Applications of New Approach Methodologies (NAMs) in Chemical Safety Assessment: Applying US EPA Tools and Approaches in Practice. Presentation given to the The American Society for Cellular and Computational Toxicology (ASCCT) annual meeting October 23 ...
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The Journal of Internationalization and Localization, 2016
Higher Education institutions worldwide are aware of the fact that intercultural and interdisciplinary collaborations will be an essential part of their students’ professional lives. To that effect, it is crucial to develop pedagogical strategies to provide students with the skills that will give them the mobility and flexibility to operate efficiently
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Higher Education institutions worldwide are aware of the fact that intercultural and interdisciplinary collaborations will be an essential part of their students’ professional lives. To that effect, it is crucial to develop pedagogical strategies to provide students with the skills that will give them the mobility and flexibility to operate efficiently
openaire +1 more source
Transitioning towards objective read-across approaches: Generalised Read-across (GenRA)
2019Presentation given to the European Food Safety Authority (EFSA) webinar held on September 6 ...
Helman, George +2 more
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2016
Read-across has become popular since the introduction of regulations, such as the European REACH regulation. This chapter provides instructions on how to use ToxRead, new freely available software for read-across analysis, and on how to interpret its output predictions for mutagenicity assessments.This tool offers two seminal sources: a set of rules ...
Serena, Manganelli, Emilio, Benfenati
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Read-across has become popular since the introduction of regulations, such as the European REACH regulation. This chapter provides instructions on how to use ToxRead, new freely available software for read-across analysis, and on how to interpret its output predictions for mutagenicity assessments.This tool offers two seminal sources: a set of rules ...
Serena, Manganelli, Emilio, Benfenati
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Reading comprehension across languages
Written Language & Literacy, 2019AbstractOrthographic depth, the degree of spelling-to-sound consistency in a language, has been hypothesized to affect the ease with which children learn to read words. However, the relationship between orthographic depth and reading comprehension is less well understood. In this study, focusing on countries in which two international assessments (PISA
Nicola A. McClung, P. David Pearson
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2002
In the aftermath of the September 11, 2001 terrorist attacks on the World Trade Center and the Pentagon, the 5,000-mile U.S. border with Canada has been elevated to an unprecedented place of prominence in the American public consciousness. The closing of crossing points, long delays for cross-border traffic, and detailed searches at ports of entry in ...
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In the aftermath of the September 11, 2001 terrorist attacks on the World Trade Center and the Pentagon, the 5,000-mile U.S. border with Canada has been elevated to an unprecedented place of prominence in the American public consciousness. The closing of crossing points, long delays for cross-border traffic, and detailed searches at ports of entry in ...
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Lexical integration across saccades in reading
Psychological Research, 1990Eye movements were recorded during sentence reading to examine the integration of parafoveal text across fixations. Four viewing conditions were used, each affording full view of the directly fixated word: no preview of the spatially adjacent parafoveal word; preview of its beginning trigram; preview of its beginning four letters; or preview of all its
A W, Inhoff, S, Tousman
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2011
This chapter is self reflective in that it considers what Ii can learn about furthering teacher development by revisiting and bringing together two collections of drawings that show how young people view HIV and AIDS. These drawings were produced in the From Our Frames and Youth as Knowledge Producers projects.
Jean Stuart, Ann Smith
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This chapter is self reflective in that it considers what Ii can learn about furthering teacher development by revisiting and bringing together two collections of drawings that show how young people view HIV and AIDS. These drawings were produced in the From Our Frames and Youth as Knowledge Producers projects.
Jean Stuart, Ann Smith
openaire +1 more source