Results 41 to 50 of about 4,178,128 (285)

Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment

Nanomaterials, 2020
Transcriptomics data are relevant to address a number of challenges in Toxicogenomics (TGx). After careful planning of exposure conditions and data preprocessing, the TGx data can be used in predictive toxicology, where more advanced modelling techniques
Angela Serra, Michele Fratello, Luca Cattelani, Irene Liampa, Georgia Melagraki, Pekka Kohonen, Penny Nymark, Antonio Federico, Pia Anneli Sofia Kinaret, Karolina Jagiello, My Kieu Ha, Jang-Sik Choi, Natasha Sanabria, Mary Gulumian, Tomasz Puzyn, Tae-Hyun Yoon, Haralambos Sarimveis, Roland Grafström, Antreas Afantitis, Dario Greco   +19 more
doaj   +1 more source

Short-read and long-read full-length transcriptome of mouse neural stem cells across neurodevelopmental stages

Scientific Data, 2022
Measurement(s) transcriptomic datasets of neural stem cells Technology Type(s) Next-Generation Sequencing(NGS) • third-generation full-length sequencing(TGS) Sample Characteristic - Organism Mus musculus Sample Characteristic - Environment laboratory ...
Chaoqiong Ding, Xiang Yan, Mengying Xu, Ran Zhou, Yuancun Zhao, Dan Zhang, Zongyao Huang, Zhenzhong Pan, Peng Xiao, Huifang Li, Lu Chen, Yuan Wang   +11 more
doaj   +1 more source

Grouping of nanomaterials to read-across hazard endpoints: from data collection to assessment of the grouping hypothesis by application of chemoinformatic techniques

Particle and Fibre Toxicology, 2018
Background An increasing number of manufactured nanomaterials (NMs) are being used in industrial products and need to be registered under the REACH legislation.
L. Lamon, D. Asturiol, A. Richarz, E. Joossens, R. Graepel, K. Aschberger, A. Worth   +6 more
doaj   +1 more source

Simulated gastric hydrolysis and developmental toxicity of dimethyltin bis(2-ethylhexylthioglycolate) in rats

Frontiers in Toxicology, 2023
Dimethyltin dichloride is used as the putative toxophore for dimethyltin bis-alkylthio esters in a read-across approach. Recent chemical and toxicological investigations challenges this read across as data on dioctyltin bis(2-ethylhexyl thioglycolate ...
Dominik Kirf, Richard Costlow, Hans Nasshan, Peter Frenkel, Donna Mondimore   +4 more
doaj   +1 more source

Supporting read-across using biological data [PDF]

ALTEX, 2016
Read-across, i.e. filling toxicological data gaps by relating to similar chemicals, for which test data are available, is usually done based on chemical similarity. Besides structure and physico-chemical properties, however, biological similarity based on biological data adds extra strength to this process. In the context of developing Good Read-Across
Zhu, Hao, Bouhifd, Mounir, Donley, Elizabeth, Egnash, Laura, Kleinstreuer, Nicole, Kroese, E. Dinant, Liu, Zhichao, Luechtefeld, Thomas, Palmer, Jessica, Pamies, David, Shen, Jie, Strauss, Volker, Wu, Shengde, Hartung, Thomas   +13 more
openaire   +4 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright, Morgan A. Paul, Selena Murcia Mendez, Emily Jones, Lucille Lokko, Chelsea Heneghan, Nicholas Purol, Morgan Arnold, Rahela Aziz‐Bose, Colleen A. Kelly, Sandi L. Pruitt, Joanne Wolfe, Kira Bona, Puja J. Umaretiya   +13 more
wiley   +1 more source

Early Reading Proficiency in the United States [PDF]

, 2014
Children who read proficiently by the end of third grade are more likely to graduate from high school and tobe economically successful in adulthood. This report provides an update on how fourth graders are faring in reading across the nation and in each ...

core  

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Physiologically based kinetic (PBK) modeling of propiconazole using a machine learning-enhanced read-across approach for interspecies extrapolation

Environment International
A significant challenge in the traditional human health risk assessment of agrochemicals is the uncertainty in quantifying the interspecies differences between animal models and humans.
Yaoxing Wu, Gabriel Sinclair, Raghavendhran Avanasi, Alison Pecquet   +3 more
doaj   +1 more source