Results 71 to 80 of about 467,593 (251)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Influential factors in individual differences in reading comprehension: cognitive inhibition and working memory

open access: yesRevista MENDIVE, 2017
To read involves understanding of what it is read; automation of the processes involved in reading, lead us to believe that it is a simple process. Thepeople, to read uses encoding and decoding processes: recognizing and decoding words graphemes allowing
Carlos Wilfrido Guevara Toledo
doaj  

Ferroelectric capacitive memories: devices, arrays, and applications

open access: yesNano Convergence
Ferroelectric capacitive memories (FCMs) utilize ferroelectric polarization to modulate device capacitance for data storage, providing a new technological pathway to achieve two-terminal non-destructive-read ferroelectric memory.
Zuopu Zhou   +11 more
doaj   +1 more source

Design and Analysis of an Ultra-Dense, Low-Leakage, and Fast FeFET-Based Random Access Memory Array

open access: yesIEEE Journal on Exploratory Solid-State Computational Devices and Circuits, 2019
High static power associated with static random access memory (SRAM) represents a bottleneck in increasing the amount of on-chip memory. Novel, emerging nonvolatile memories such as spintransfer torque magnetic random access memory (STT-RAM), resistive ...
Dayane Reis   +11 more
doaj   +1 more source

Readout of solid-state charge qubits using a single-electron pump

open access: yes, 2007
A major difficulty in realizing a solid-state quantum computer is the reliable measurement of the states of the quantum registers. In this paper, we propose an efficient readout scheme making use of the resonant tunneling of a ballistic electron produced
C Hines   +7 more
core   +1 more source

Continuous-variable phase-estimation with unitary and random linear disturbance [PDF]

open access: yes, 2014
We address the problem of continuous-variable quantum phase estimation in the presence of linear disturbance at the Hamiltonian level, by means of Gaussian probe states.
de Souza, Douglas Delgado   +2 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Microminiature thermocouple monitors own installation [PDF]

open access: yes, 1966
Microminiature thermocouple makes precision gas sidewall temperature readings inside large thrust chambers. It is installed by a technique whereby the sensor monitors its own installation to insure against thermal damage to the thermocouple and ensure ...
Garrett, A. J., Sellers, J. P., Jr.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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