Results 121 to 130 of about 652,796 (302)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A new capacitive read-out for EXPLORER and NAUTILUS

, 2006
We describe the present status of a new read-out for the EXPLORER and NAUTILUS gravitational wave detectors. The read-out is based on a double-gap capacitive transducer and a double-SQUID amplifier.
FAFONE, VIVIANA, Torrioli, G., Sanjust, F, Minenkov, Y., Sanjust, F., BASSAN, MASSIMO, Bassan, M, Torrioli, G, Carelli, P, Fafone, V, Carelli, P., Minenkov, Y, Pallottino, GV, Rocchi, A., Rocchi, A   +14 more
core   +1 more source

Detecting haplotype-specific transcript variation in long reads with FLAIR2

Genome Biology
Background RNA-seq has brought forth significant discoveries regarding aberrations in RNA processing, implicating these RNA variants in a variety of diseases.
Alison D. Tang, Colette Felton, Eva Hrabeta-Robinson, Roger Volden, Christopher Vollmers, Angela N. Brooks   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tomtit‐Raven Evolutionary Selector‐Reinforced Attention‐Driven: A High‐Performance and Computationally Efficient Cyber Threat Detection Framework for Smart Grids

Energy Science & Engineering
Identifying cyber threats maintains the security and operational stability of smart grid systems because they experience escalating attacks that endanger both operating data reliability and system stability and electricity grid performance.
Priya R. Karpaga, Praveen Kumar Balachandran, Umawathy Techanamurthy, Muhammad Ammirrul Atiqi Mohd Zainuri   +3 more
doaj   +1 more source

Letter to the editor: radiomics signature for dynamic monitoring of tumor-inflamed microenvironment and immunotherapy response prediction

Journal for ImmunoTherapy of Cancer
We read with great interest the article by Bernatowicz et al. Despite the promising findings, we would like to highlight several concerns regarding the methodology and interpretation of the results that warrant further discussion, including the stability
Shuixing Zhang, Yuhao Dong
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Asymmetrical FinFET SRAM cells with wider read noise margin and lower leakage currents

, 2015
Degraded data stability, weaker write ability, and increased leakage power consumption are the primary concerns in scaled static random-access memory (SRAM) circuits. Two new FinFET memory circuits with asymmetrically gate underlap engineered transistors
Shairfe Muhammad Salahuddin, Kursun, Volkan, Salahuddin, Shairfe Muhammad, Volkan Kursun   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Eight-FinFET fully differential SRAM cell with enhanced read and write voltage margins

, 2015
An eight-FinFET fully differential SRAM cell is proposed in this paper to achieve stronger data stability and enhanced write ability. The p-type transistors are used for data access during read operations and transmission gates are employed to force new ...
Chan, Mansun, Salahuddin, Shairfe Muhammad   +1 more
core   +1 more source