Results 61 to 70 of about 5,801,512 (242)
Reader-Response Criticism in the Teaching of Poetry [PDF]
, 1992 The focus of this project is on the use of the reader-response orientation in the development of a poetry unit for grade seven. The reader-response orientation is a literary theory which suggests that the meaning of any literary work is the result of ...
Paas, Steve
core +1 more source
The Role of Implied Reader in the Realm of Literary Criticism [PDF]
پژوهشنامۀ انتقادی متون و برنامههای علوم انسانی, 2018 This article aims to examine the process of text reading and understanding, based on the concept of implied reader, for the definition of which, we have synthesized herein the seemingly antithetical methods of ‘authorial’ and ‘reader-oriented’ criticism.
Hossein Safi Pirlooje
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Language and Psychoanalysis, 2013 Language students tend to struggle with literature because they find psychological and socio-cultural implications embedded in literary texts difficult to understand and discuss (Kramsch, 1996).
Lubie Grujicic-Alatriste
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
«Reader! Bruder!»: The Rhetoric of Narration and the Rhetoric of Reading
Between, 2014 The paper deals with the relation of power established by narrative texts, exploring the many-sided field of articulation among the related subjects: the narrator as a subject of power, the text as a rhetorical device, and the reader as an ultimate ...
Federico Bertoni
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source