Results 111 to 120 of about 956,174 (309)
The Compounding Pain of Familial Betrayal and Institutional Failure in Nigerian Rape Narratives
ABUAD Journal of the Humanities-AGIDIGBOThis article examines the representation of rape in Nigerian literature, a topic often shrouded in cultural silence and stigma. It argues that selected Nigerian novels provide a crucial platform for exposing the compounded pain of sexual violence, a ...
Edith Abisola AWOGU-MADUAGUW +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Bakhtin as a theory of reading [PDF]
, 1993 Includes bibliographical references (p ...
Davidson, Judith
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
A Reciprocal Intercommunication between Reader and Writer: A Critical Study of Cyber Literature
European Journal of Volunteering and Community-Based Projects, 2022 Since the accessibility of the internet, cyber literature can be an act of bringing ease, evolving preferences and mindsets. This research may be a survey focused on the opinions of the respondents on the nature of social media cyber literature; of its ...
Jamirul Islam
doaj
E-Motion: being moved by fiction and media? : Notes on fictional worlds, virtual contacts and the reality of emotions [PDF]
, 2008 Our response to fictional cues is often as emotional as to occurrences in real life. Such emotional responses do not mean that each time we mistake fiction for reality; rather they are affected by our innate social behaviors and by complex neural ...
Mellmann, Katja
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Graphic Novel Adaptations And The Crisis Of The Ideal Reader: A Reception Theory Analysis
The Journal of Studies in Language, Culture and SocietyGraphic novel adaptations of canonical literary works challenge fundamental assumptions within contemporary reception theory, particularly the privileged status of the ideal reader construct. This paper examines how graphic novels expose the limitations
Hichem Souhali
doaj