Results 91 to 100 of about 10,603,142 (281)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
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WISE BLOOD THROUGH THE LENS OF READER RESPONSE THEORY [PDF]
Flannery O’Connor’s 1952 novel, Wise Blood, is a frequently misunderstood classic. While O’Connor is very rarely associated with reader response theory, its framework offers a way to more fully appreciate O’Connor as an author and Wise Blood as a novel ...
Stewart, Hannah Rose Horton
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Race, storying, and restorying: What can we learn from Black fans?
Transformative Works and Cultures, 2019 Tracing storytelling traditions from historic roots within Black cultures to contemporary fandom, this essay argues for more research and critique on the ways that today's Black fans engage in restorying, with implications for reader response theory ...
Ebony Elizabeth Thomas, Amy Stornaiuolo
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Reader-Response Criticism: Reader, Response and Interpretation
, 2019 © 2019 Karadeniz Technical University. All rights reserved.Reader-response criticism is not a conceptually unified critical position. Its theory is instead associated with the work of critics who use the reading process and response to centralize the ...
BAKTIR, HASAN
core
The Compounding Pain of Familial Betrayal and Institutional Failure in Nigerian Rape Narratives
ABUAD Journal of the Humanities-AGIDIGBOThis article examines the representation of rape in Nigerian literature, a topic often shrouded in cultural silence and stigma. It argues that selected Nigerian novels provide a crucial platform for exposing the compounded pain of sexual violence, a ...
Edith Abisola AWOGU-MADUAGUW +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Reassessing Reception Theory and Reader-Response Criticism.
, 2009 تبحث هذه المقالة في نظريةُ التلقي واستجابة القارئَ النقدية التي ما تزال ضرورية حتى وقتنا هذا في بداية القرنِ الحادي والعشرينِ، العصر المفعم بثقافةِ الإنترنتِ التي تفترضُ أن المعلوماتِ يُمْكِنُ أَنْ تُستَرجعَ مِنْ الكُتُبِ أَو الحاسباتِ، إذ لايزال الإنسان
سلامي, محمود
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FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source