Results 71 to 80 of about 10,603,142 (281)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Journal of Curriculum Theorizing, 2017 This book review of Kathy Short’s and Dana Fox’s collection of essays on multicultural literature (Stories Matter, 2003) offers a summary of the views expressed and finds that authors in the debate over what counts as multicultural literature take up ...
Jacquelyn Chappel
doaj +1 more source
Revisiting Reader Response Theory
Creative SaplingsThe role of readers in literary studies was not prominently recognized and actualized in the conventional practice. The focus was on the writer both as the creator of literary texts and interpreter of literary texts. The writer was the source of creative writing and its meaning.
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, 1992 Literature and our relationship to it have long been subjects of interest and exploration to readers, teachers, and critics. Theories of literary criticism have attempted to describe this relationship by ascribing varying degrees of prominence to the reader, the text and the teacher/critic. Common to most theories of literary criticism is the degree of
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 1910 Two documents attached together (1 to honorable TB Ferguson from George W. Fowler and (2 letter of receipt from Ben R. Reader (
Fowler, George, Reader, Ben R.
core
Actualizing Reader-Response Theory on L2 Teacher Training Programs
TESL Canada Journal, 2012 In this article we share our experiences of using poems in teacher-training courses where the students are predominantly second-language learners. We describe how we tried to help learners engage with a creative text through its language and meaning. We share our experiences of helping to facilitate the open expression of opinions and feelings in L2 ...
Chu, B, Harfitt, G
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A Reciprocal Intercommunication between Reader and Writer: A Critical Study of Cyber Literature
European Journal of Volunteering and Community-Based Projects, 2022 Since the accessibility of the internet, cyber literature can be an act of bringing ease, evolving preferences and mindsets. This research may be a survey focused on the opinions of the respondents on the nature of social media cyber literature; of its ...
Jamirul Islam
doaj +2 more sources