Results 51 to 60 of about 57,442 (257)
Educare, 2011 The purpose of this study is to contribute to the knowledge about the importance of listening in modern sound technology and the importance of tradition in reception analysis of literary conversations.
Kent Adelmann
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Actualizing Reader-Response Theory on L2 Teacher Training Programs
TESL Canada Journal, 2012 In this article we share our experiences of using poems in teacher-training courses where the students are predominantly second-language learners. We describe how we tried to help learners engage with a creative text through its language and meaning. We share our experiences of helping to facilitate the open expression of opinions and feelings in L2 ...
Chu, B, Harfitt, G
openaire +3 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The Hound of the Baskervilles : Histoire, fantasme et genèse de la narration policière
Sillages Critiques, 2004 Through one of the most famous Sherlock Holmes stories, we can shed light on some typical features in the narrative system of detective stories, especially concerning Watson as an unreliable narrator, once more fooled by Sherlock Holmes here in many ...
Christophe Gelly
doaj +1 more source
, 1992 Literature and our relationship to it have long been subjects of interest and exploration to readers, teachers, and critics. Theories of literary criticism have attempted to describe this relationship by ascribing varying degrees of prominence to the reader, the text and the teacher/critic. Common to most theories of literary criticism is the degree of
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Journal of Curriculum Theorizing, 2017 This book review of Kathy Short’s and Dana Fox’s collection of essays on multicultural literature (Stories Matter, 2003) offers a summary of the views expressed and finds that authors in the debate over what counts as multicultural literature take up ...
Jacquelyn Chappel
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source