Results 61 to 70 of about 10,603,142 (281)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Playing Pirates with Tom Sawyer: The Intersection of Reader-Response Theory and Play Theory
, 2017 Mark Twain's The Adventures of Tom Sawyer tells the story of a boy's adventures in a Midwestern American town during the mid-nineteenth century, but it also provides an insightful account of how many children respond to literature.
Mark I. West (21597257)
core +1 more source
The Reader in Focus : Rosenblatt's reader-response theory as "narrative imagination"?
, 2014 In this thesis – concerning didactics of literature – I perform a reading and theoretical analysis of two pivotal works within reader-response theory, more precisely: Literature as Exploration (1938) and The Reader, the Text, the Poem – The Transactional
Öhman, Niklas
core +4 more sources
The Reader: an exploration of the history and present place of Reader ministry in the Church of England [PDF]
, 2010 A substantial part of the Church of England ministry is provided by Readers, but little information is available about their past or present position in the church.
Garner, Peter
core +4 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Educare, 2011 The purpose of this study is to contribute to the knowledge about the importance of listening in modern sound technology and the importance of tradition in reception analysis of literary conversations.
Kent Adelmann
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Reader response in the classroom [PDF]
, 2020 Reader response has tended to be presented as one among a range of different literary theories – and often as part of the theoretical turn in the 1960s and 1970s. What is meant by reader response theory, however, is so hugely variable as to call into
Yandell, John
core +1 more source
The Hound of the Baskervilles : Histoire, fantasme et genèse de la narration policière
Sillages Critiques, 2004 Through one of the most famous Sherlock Holmes stories, we can shed light on some typical features in the narrative system of detective stories, especially concerning Watson as an unreliable narrator, once more fooled by Sherlock Holmes here in many ...
Christophe Gelly
doaj +1 more source