Results 61 to 70 of about 57,442 (257)

A Reciprocal Intercommunication between Reader and Writer: A Critical Study of Cyber Literature

European Journal of Volunteering and Community-Based Projects, 2022
Since the accessibility of the internet, cyber literature can be an act of bringing ease, evolving preferences and mindsets. This research may be a survey focused on the opinions of the respondents on the nature of social media cyber literature; of its ...
Jamirul Islam
doaj   +2 more sources

A virtual roundtable on Iser’s legacy Part I: conversation with Gerald Prince

Enthymema, 2017
In this article you find the first part of a roundtable on Wolfgang’s Iser legacy with Gerald Prince, Mark Freeman, Marco Caracciolo and Federico Bertoni. In Part I we discuss with Prof.
Gerald Prince, Laura Lucia Rossi
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Empathy translation in traditional Chinese medicine: Reader reception and paradigm building through the English translations of Shang Han Lun

New Techno-Humanities
This study investigates the emotional and cognitive reception of Shang Han Lun translations among global readers and explores how translation strategies can be optimized to enhance affective resonance and cultural intelligibility.
Tong Zhou, Jinghui Wang
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Syntax of Shadows  of the Unwritten Text in Postmodern Narratives.

مجلة اداب ذي قار
Using three main theoretical frameworks, this essay investigates the postmodern literature's instability of meaning and diversity of interpretation: Deconstruction, Intertextuality, and Reader-Response Theory.
Jameel Ibrahim Hassen
doaj   +1 more source

Euthanasia and Reincarnation: A Reader - Response Reading of Poe’s “The Tell- Tale Heart” [PDF]

Transcultural Journal of Humanities and Social Sciences
This paper sheds light on the reader as a crucial side of the triangle which includes: the reader, the text, and the author. Firstly, I highlight the contours of the reader – response theory by the prominent theorist Wolfgang Iser who stresses the role ...
Faten Dahy
doaj   +1 more source

Revisiting Reader Response Theory

Creative Saplings
The role of readers in literary studies was not prominently recognized and actualized in the conventional practice. The focus was on the writer both as the creator of literary texts and interpreter of literary texts. The writer was the source of creative writing and its meaning.
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source