Results 151 to 160 of about 1,154,560 (308)

First Reader Second Reader

, 2006
The first steps toward widsom are the most strenuous, because our weak and stubborn souls dread exertion (without absolute guarantee of reward) and the unfamiliar.
Wei Qin Ph. D, Martin Herbordt Ph. D, Fourth Reader, Douglas Michael Disabello, Third Reader   +4 more
core  

Methodological quality of cardiac CT and MRI radiomics studies assessed using METRICS and RQS by human readers and ChatGPT 5.1 Thinking. [PDF]

Eur Radiol Exp
Garello LF, Giannini V, Gatti M, Defeudis A, Cafaro D, Nicoletti G, Culasso NC, Faletti R, Veltri A, Cuocolo R, Balbi M.   +10 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Improved image quality and T-staging accuracy using FOCUS-MUSE DWI in gastric cancer: a prospective comparison with SS-EPI. [PDF]

Eur Radiol Exp
Li Q, Hou YJ, Jiang QY, Xu J, Feng QX, Yuan L, Wu PY, Wu CJ, Liu XS, Sun NN.   +9 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

"His and My Reader": Rereading Pale Fire hypertextually

, 2012
Traditionally, Pale Fire scholarship has focused on the question of authorship, ignoring the markers within the text referring to various readers of the text.
Rowberry, Simon
core  

Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis. [PDF]

PLOS Glob Public Health
Palmer M, Derks I, Schaaf HS, Goussard P, Jaganath D, Kik SV, Gibb DM, Turkova A, Walters E, van der Zalm MM, Hesseling AC, Seddon JA.   +11 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Radiologists' memory as a data protection risk: a worst-case stress test for chest radiograph re-identification. [PDF]

Insights Imaging
Fink MA, Römer C, Ebel M, Frodl E, Dos Santos DP, Kauczor HU, Bucher A.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source