Results 91 to 100 of about 422,269 (304)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Poetry's total scandal:Poets and postmen in Antonio Skármeta’s El cartero de Neruda [PDF]

, 2012
The argument put forward here takes Antonio Skármeta's short novel El cartero de Neruda (Con ardiente paciencia) as a theorization of the relationship between poetry and politics, by way of the concept-metaphors (Mieke Bal) that are deployed in the novel.
Gräbner, Cornelia
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Taking Risks. A Reading of Oscar Wilde's The Picture of Dorian Gray

Miscelánea: A Journal of English and American Studies, 1994
The aim of this paper is to analyse Oscar Wilde's The Picture of Dorian Gray  from a postmodernist standpoint. By drawing on a variety of critical  perspectives, such as psychoanalysis, deconstruction, and reader-response  criticism, it tries to suggest
Isabel Fraile Murlanch
doaj   +1 more source

The Relationship Between Ethics and Literature in Light of Levinas’s Work [PDF]

, 2015
In my paper I intend to uncover the relationship between ethics and literature. The aforementioned issue is connected to ’ethical turn’ — new orientation in literary studies, which was introduced in the nineties of 20th century.
Walczak, Maria
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Kryminalny teatr teorii Normana Hollanda

Annales Universitatis Paedagogicae Cracoviensis. Studia Poetica, 2019
Artykuł skupia się na Death in a Delphi Seminar: A Postmodern Mystery (1995) Normana N. Hollanda oraz na relacjach między tą powieścią i Hollandowską wersją reader-response theory.
Anna Skubaczewska-Pniewska
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

НОРМАН Н. ГОЛЛАНД. ЄДНІСТЬ ІДЕНТИЧНІСТЬ ТЕКСТ Я-САМ

Синопсис: текст, контекст, медіа, 2014
Переклад із англійської та коментарі Людмили Анісімової   Перекладено за виданням: Norman N. Holland. UNITY IDENTITY TEXT SELF // Reader-response criticism: From Formalism to Post-Structuralism / Ed. Jane P. Tompkins.
Liudmyla Anisimova
doaj