Results 131 to 140 of about 6,236,073 (332)

Using a RESTful messaging and registry system to support a range a distributed applications

open access: yesRevista Colombiana de Computación, 2010
Tycho was conceived in 2003 in response to a need by the GridRM [1], a resourcemonitoring project for a “light-weight”, scalable and easy to use wide-area distributed registry and messaging system.
Mark Baker   +5 more
doaj  

A Machine Learning Framework to Evaluate Vegetation Modeling in Earth System Models

open access: yesJournal of Advances in Modeling Earth Systems
Vegetation gross primary productivity (GPP) is the single largest carbon flux of the terrestrial biosphere which, in turn, is responsible for sequestering 25%–30% of anthropogenic carbon dioxide emissions.
Ranjini Swaminathan   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

In Memoriam: Professor Emeritus Philip Adams

open access: yesAustralasian Orthodontic Journal, 1998
Reading John
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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