Results 101 to 110 of about 93,418 (279)

Two independent mechanisms for motion-in-depth perception : evidence from individual differences [PDF]

open access: yes, 2010
Our forward-facing eyes allow us the advantage of binocular visual information: using the tiny differences between right and left eye views to learn about depth and location in three dimensions.
Harris, Julie   +2 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Periodic letter strokes within a word affect fixation disparity during reading [PDF]

open access: yes, 2010
We investigated the way in which binocular coordination in reading is affected by the spatial structure of text. Vergence eye movements were measured (EyeLink II) in 32 observers while they read 120 single German sentences (Potsdam Sentence Corpus ...
Jainta, S, Jaschinski, W, Wilkins, AJ
core   +1 more source

Visual and Refractive Outcomes following Bilateral Implantation of Extended Range of Vision Intraocular Lens with Micromonovision

open access: yesJournal of Ophthalmology, 2018
Purpose. To evaluate the outcomes following bilateral ERV intraocular lens implantation with micromonovision. Methods. 25 subjects underwent bilateral Tecnis Symfony IOL implantation with micromonovision.
Sri Ganesh   +3 more
doaj   +1 more source

Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests.

open access: yesPLoS ONE, 2020
The purpose of the study was to evaluate the diagnostic accuracy of visual function tests in intermediate age-related macular degeneration (iAMD).
Susanne G Pondorfer   +6 more
doaj   +1 more source

Questions and Answers About Blindness and Vision Impairments in the Workplace and the Americans with Disabilities Act [PDF]

open access: yes, 2005
The Americans with Disabilities Act (ADA) is a federal law that prohibits discrimination on the basis of disability. Title I of the ADA makes it unlawful for any employer to discriminate against a qualified applicant or employee because of a disability ...

core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Skim reading: an adaptive strategy for reading on the web

open access: yes, 2014
It has been suggested that readers spend a great deal of time skim reading on the Web and that if readers skim read they reduce their comprehension of what they have read.
Drieghe, Denis   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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