Results 61 to 70 of about 28,760 (245)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of levodopa and deep brain stimulation on visual impairments in Parkinson’s disease

Clinical Parkinsonism & Related Disorders
Background: Parkinson’s disease (PD) often causes visual changes that impair visuospatial processing, reading speed, and contrast acuity, impacting patients’ quality of life.
Sana Aslam, Markey Olson, Melissa Kovacs, Pireh Ansari, Amputch Karukote, Justine Chan, Shadi Barbu, Sydney Felsen, Holly A. Shill, Charles H. Adler   +9 more
doaj   +1 more source

Effect of Myopic Undercorrection on Habitual Reading Distance in Schoolchildren: The Hong Kong Children Eye Study

Ophthalmology and Therapy, 2022
Introduction This study aimed to evaluate the habitual reading distance among non-myopic children and also myopic children with undercorrection and with full correction.
Shu Min Tang, Xiu Juan Zhang, Yu Meng Wang, Yuzhou Zhang, Lok Man Wong, Hei-Nga Chan, Bi Ning Zhang, Wai Kit Chu, Ka Wai Kam, Alvin L. Young, Clement C. Tham, Li Jia Chen, Amanda N. French, Kathryn A. Rose, Chi Pui Pang, Jason C. Yam   +15 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Reading from a Head-Fixed Display during Walking: Adverse Effects of Gaze Stabilization Mechanisms. [PDF]

PLoS ONE, 2015
Reading performance during standing and walking was assessed for information presented on earth-fixed and head-fixed displays by determining the minimal duration during which a numerical time stimulus needed to be presented for 50% correct naming answers.
Olivier Borg, Remy Casanova, Reinoud J Bootsma   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Simulation of Thalamic Prosthetic Vision: Reading Accuracy, Speed and Acuity in Sighted Humans

Frontiers in Human Neuroscience, 2014
The psychophysics of reading with artificial sight has received increasing attention as visual prostheses are becoming a real possibility to restore useful function to the blind through the coarse, pseudo-pixelized vision they generate.
Milena eVurro, Milena eVurro, Anne Marie eCrowell, John S Pezaris, John S Pezaris   +4 more
doaj   +1 more source

[Development and validation of the MNREAD reading acuity chart in Portuguese].

Arquivos brasileiros de oftalmologia, 2007
To create and to validate a version of the Minnesota Low Vision Reading Test (MNREAD) acuity chart for the Portuguese language.The Minnesota Low Vision Reading Test acuity chart contain 19 sentences (logMAR 0.5 to 1.3) with 60 characters printed on three lines. All the sentences must have the same length with simple vocabulary. A total of 110 sentences
Celina Tamaki Monteiro de, Castro, Christopher Scott, Kallie, Solange Rios, Salomão   +2 more
openaire   +2 more sources