Results 121 to 130 of about 2,117,382 (314)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

"Creating something else to be" : negotiating African American female subjectivities in Toni Morrison's Sula, Beloved, and Jazz : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in English at Massey University [PDF]

, 1996
Toni Morrison's novels, Sula, Beloved, and Jazz delineate the struggles of African American women to attain subject positions in a society where blackness and femaleness mark them as 'others,' and where women are objectified in the male pursuit of ...
Smith, Angela Marie
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Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Private initiative as a growth factor of Book publishing activity in Russia in the last third of the 18th century

Вестник Тамбовского университета. Серия: Гуманитарные науки
Importance. A landmark event in the history of Russia in the last third of the 18th century was the development of private printing houses, which destroyed the state and church monopoly on printing publications.
R. M. Zhitin, A. G. Topilsky
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

It’s Kind of Like a Comfort Blanket

Study and Scrutiny
This qualitative study uses semi-structured interviews with 26 adult readers of the Harry Potter series, to explore how pleasure reading in childhood and adolescences impacts reading lives, autonomy, competency, and relatedness years after first ...
Rebekah Buchanan
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The Bookmarker App: my e-reading diary: librarians’ experiences

Čitalište
The paper focuses on researching the implementation of the application „Bookmark: My E-Reading Diary” within the context of a multidisciplinary project conducted in five public libraries in Serbia.
Vesna Milanović Simičić
doaj   +1 more source

Optimalisasi Fungsi Pojok Baca Di Kelas I SD Muhammadiyah Pangkalpinang Sebagai Penumbuhkenalkan Budaya Membaca [PDF]

, 2018
This study aims to describe 1) the effort of the school to introduce the reading culture of the students I SD Muhammadiyah Pangkalpinang 2) the function of reading corner I SD Muhammadiyah Pangkalpinang 3) obstacles in optimizing the function of reading ...
-, Nur Amalia, S.S., M.Teach., Pamungkas, Bintang   +1 more
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