Results 131 to 140 of about 444,355 (314)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Revisiting the Mutual Embeddedness of Culture and Mental Illness
, 2012 In this paper, we discuss the intricate relationship between culture and mental illness. Our central position is that there cannot be mental illness without culture.
David Lackland Sam +3 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Functions of reading and adults' reading interests
, 2011 [[abstract]]Using a nationally representative sample in Taiwan, this study found that adult Taiwanese read non-narrative books more often than narrative books. More importantly, this study established associations between functions of reading and reading
Chen, S. Y
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Research and theory driven insights: ten suggestions for L2 reading instruction
, 2007 Research and theory on second language reading has reached heightened dimensions in recent years. It is through reading that learners access much information concerning the target language and culture, and consequently reading is an important part of ...
White, Violaine +5 more
core
Cultural change and reading. Heading towards a new reading culture
Education in the Knowledge Society, 2017 The current limitations to the reading practices can probably best be appreci- ated within the cultural changes coinciding with the step from a modern society to a post modern one. These technologies of daily life are changing the way we work, we interact and we live.
openaire +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
The effect of reading on a group of young men: how does it influence selfhood
, 2010 This thesis is concerned with examining what the influence of reading is, on those young men who choose to read. Looking at the responses of a number of young men, a tripartite approach details the reading history of each respondent, discusses ...
Robinson-Harris, Joan
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source