Results 71 to 80 of about 444,355 (314)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

The social construction of meaning : Reading Animal Farm in the classroom [PDF]

open access: yes, 2013
The novel, it has generally been assumed, was from its very beginnings a literary form designed to be read by solitary, silent individuals. One consequence of this assumption is that the class novel, read amid all the noise and sociality of the classroom,
Yandell, John
core  

'A different kind of reading': the emergent literacy practices of a school-based graphic novel club

open access: yes, 2013
This paper explores the possibilities for pedagogy inherent in the reading practices which emerged from an extra-curricular graphic novel reading group set up in a Scottish secondary school.
Sabeti, Shari   +2 more
core   +1 more source

MODERN FICTION AS FACTOR OF STUDENTS’ READING CULTURE DEVELOPMENT

open access: yesNovìtnâ Osvìta, 2016
Nowadays there is an urgent need for the formation of students’ reading culture in a modern university. It is necessary to enhance the educational value of a book in students, who are losing their interest in reading.
Galyna Bilavych, Iryna Rozman
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The Role of College English Textbooks in the Teaching of Culture in China [PDF]

open access: yes, 2010
The teaching of culture is one of the most important parts of English Language Teaching. It is unavoidable and necessary because English and culture are closely related and communication in English requires intercultural competence.
Jiang, Bo
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Reading the Scottish Enlightenment : libraries, readers and intellectual culture in provincial Scotland c.1750-c.1820

open access: yes, 2008
The thesis explores the reception of the works of the Scottish Enlightenment in provincial Scotland, broadly defined, aiming to gauge their diffusion in the libraries of private book collectors and 'public' book-lending institutions, and to suggest the ...
Towsey, Mark R. M.
core  

On Reading Reading: Fundamental Problems of “Méta-lecture”

open access: yes
In his essay “Sur la Lecture,” Roland Barthes (1984) expresses his doubts regarding what he calls “Méta-lecture,” or the reading of reading. It is nothing but “un éclat d’idées, de craintes, de désirs, de jouissances, d’oppressions.” My essay ...
Elias Kreuzmair
core   +1 more source

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