Results 61 to 70 of about 2,117,382 (314)

Modernization of the Russian education system in the first quarter of the 18th century as a factor in the book culture development

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2023
Importance. One of the most active means of modernization in Russia in the times of Peter the Great was education. To make a cultural, social, economic breakthrough, the country needed a personnel of educated and energetic specialists who understood the ...
A. G. Topilsky
doaj   +1 more source

USING PICTURE SERIES TO IMPROVE STUDENTS’ WRITING ABILITY (A Classroom Action Research at the Third Grade Students of MTS NW I Kembang Kerang in the Academic Year of 2010/2011) [PDF]

, 2011
English as the first foreign language in Indonesia is taught starting from the elementary school level up to university level. The general objective of teaching English in Indonesia, based on the school based curriculum (KTSP), is to develop students’
ZAINI, MUHAMMAD
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Analysis of Factors Influencing Parental Knowledge Enhancement and the Development of Reading Culture in Children: A Phenomenological Study [PDF]

Taṣvīr-i salāmat
Background. Reading habits established in early childhood not only enhance cognitive and academic abilities but are also acknowledged as a powerful means to improve health literacy and enable future generations to make well-informed life choices ...
Seyed Jamal Haghirosadat Toranji, Afshin Mousavi Chelak, Soraya Ziaei, Maryam Salami   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Emerging Religious Marketplace in Nigeria: A Quest for Interpretation [PDF]

, 2014
In contemporary Nigerian society, the evolving trends in Christian religious culture suggest that neoliberal (social) mind-set is influencing certain practices in many Churches.
Duke, Emmanuel Orok
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Need of Culture-Based Arabic Reading Materials by Using Multimedia in Higher Education [PDF]

, 2017
This study aimed to describe the need of culture-based Arabic reading materials by using multimedia. It used research and development approach proposed by Borg and Gall.
Emzir, E. (Emzir), Muhtarom, N. A. (Nuruddin), Tajuddin, S. (Shafruddin)   +2 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source