Results 61 to 70 of about 387,783 (268)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Learning Fable Texts through Retelling Strategies in Developing Reading Culture for Elementary School Students

Indonesian Journal of Instruction
Reading interest and reading culture are fundamental foundations for strengthening literacy from an early age in elementary school. However, students’ reading habits remain low due to learning methods that are less engaging and fail to actively involve ...
Triyuslia Hayati, Annisa Nadya Salsa Amara, Ghustyan Ghema Ramadhan, Suherli Kusmana, Mudopar Mudopar   +4 more
doaj   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Book culture of Russia and Balarus in the context of historical and cultural interaction

Библиосфера, 2013
The article describes the main activities of the Scientific Research Centre of the History of Book Culture, RAS and the Ya. Kolas Central Scientific Library of the National Academy of Sciences in the study of book culture. It also presents the results of
V. I. Vasiliev, N. Yu. Berezkina, L. A. Avgul, M. A. Ermolaeva   +3 more
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The book collection of A.N. Nortsov: the history of formation, thematic coverage and significance for the creative laboratory of the owner

Неофилология
INTRODUCTION. The book heritage of the region’s personal libraries analysis allows us to understand the reading interests’ specifics of different generations of library owners, and to clarify important aspects of the intellectual and spiritual growth of ...
R. M. Zhitin, A. G. Topilsky
doaj   +1 more source

Culture as Text: Reading and Interpreting Cultures [PDF]

, 2012
'[C]ulture as text' initially proved to be a pivotal bridging metaphor between cultural anthropology and literary studies. Following an admittedly ambivalent career path, the concept of 'culture as text' has nevertheless continued to rise and has become an over-determined general principle, an emphatic key metaphor, even an overall "programmatic motto ...
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The supply, promotion and readership of minority ethnic English language fiction in the UK: a review of the literature

Knjižnica, 2016
Purpose: Written largely from a UK perspective, this paper presents a review of the literature regarding the nature of minority writing in the English language, and its supply, promotion and readership.
Briony Birdi
doaj   +1 more source

READING ACTIVITY AND READING CULTURE

This article talked about reading activities and reading culture, educational significance of the book.
openaire   +1 more source