Results 41 to 50 of about 1,672,726 (282)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
La promoción de la lectura en las bibliotecas públicas de Medellín
Revista Interamericana de Bibliotecología, 2008 Presenta la investigación titulada Exploración de los discursos y las prácticas de la promoción de lalectura en las bibliotecas públicas de Medellín: una revisión del lugar social de la biblioteca públicaen la formación de los lectores.
Didier Álvarez Zapata +4 more
doaj
Tejuelo: Didáctica de la Lengua y la Literatura, 2022 Resumen El objetivo de este trabajo fue caracterizar las definiciones y relaciones de los conceptos de mediación, animación y promoción de la lectura para contribuir a la acotación de sus campos de acción.
Carolina González Ramírez +2 more
doaj +1 more source
Book Reading as a Factor in Encouragement of Learning Motivation of Hyperactive Students. [PDF]
, 2016 Lately primary class teachers have been facing challenges of educating hyperactive children more and more often. In primary classes, hyperactive children face learning failures, reading difficulties, weak learning motivation, they often encounter ...
Banienė, Edita,
core
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Acercamiento al estado actual de la promoción de la lectura en la biblioteca pública en Colombia
Revista Interamericana de Bibliotecología, 2008 Se presenta el resultado de la investigación sobre las actividades de promoción de la lectura que realizala biblioteca pública en Colombia. Indaga acerca de la presencia de la biblioteca en la cultura escrita yel rol desempeñado por las iniciativas de ...
Didier Álvarez Zapata +3 more
doaj
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Reading encouragement workshops in public libraries of Krapina-Zagorje County
, 2023 Cilj je ovoga rada istražiti prisutnost, vrste i obilježja programa poticanja čitanja koji se provode u narodnim knjižnicama u Krapinsko-zagorskoj županiji. Poseban naglasak stavlja se na prikaz programa u Gradskoj knjižnici Krapina, županijskoj matičnoj
Pižir, Matea
core +2 more sources