Results 61 to 70 of about 204,003 (345)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Improving the reading skills of young people with Duchenne muscular dystrophy in preparation for adulthood [PDF]

, 2014
Duchenne muscular dystrophy (DMD) is a progressive genetic condition that affects both muscle and brain. Children with DMD are at risk of psycho-social difficulties such as poor academic achievement and behavioural and socio-emotional problems.
Hoskin, J., Fawcett, Angela, Hoskin, J., Fawcett, Angela   +3 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Analysing the relationship between reading fluency and reading competence in Secondary Education

Ocnos, 2018
An adequate level of reading competence is essential to exercise fundamental rights in the hyperconnected information society of the 21st century. Reading fluency is one of the components that influences reading comprehension.
Cristina Amiama-Espaillat, Cristina Mayor-Ruiz   +1 more
doaj   +1 more source

A Comparison of Two Measures of Oral Reading Fluency [PDF]

, 2006
Reading fluency is an important part of the process of learning to read. It is commonly assessed by the use of Curriculum-Based Measurement (CBM) techniques; however, a new assessment method emerged in the Woodcock-Johnson Tests of Achievement- Third ...
Bletzinger, Kara
core   +1 more source

Fluency-Oriented Reading Instruction [PDF]

Journal of Literacy Research, 2005
This paper reports the results of a two-year project designed to reorganize basal reading instruction to stress fluent reading and automatic word recognition. The reorganized reading program had three components: a redesigned basal reading lesson that included repeated reading and partner reading, a choice reading period during the day, and a home ...
Steven A. Stahl, Kathleen M. Heubach
openaire   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Bridging the Connection between Fluency in Reading and Arithmetic

Behavioral Sciences
This study examines the contribution of early executive functions (EFs) in the association between fluency in reading and arithmetic. Kindergarten children (N = 1185) were assessed on executive functions skills and on reading and arithmetic fluency in ...
Reut Balhinez, Shelley Shaul
doaj   +1 more source

Reading aloud: eye movements and prosody [PDF]

, 2016
This study aims to connect data from ocular movements and reading aloud speech to syntactic and discursive properties of texts, in order to understand integrative cognitive processes during reading for understanding and to identify prosodic and eye ...
Costa, Armanda, Falé, Isabel, Luegi, Paula   +2 more
core   +3 more sources